Impact of gender on heart failure presentation in non-obstructive hypertrophic cardiomyopathy

AbstractHypertrophic cardiomyopathy (HCM) is a genetic cardiac disease that represents a broad spectrum of morphologic features and clinical presentations. However, little is known about the impact of gender differences in heart failure (HF) development in non-obstructive HCM. We assessed clinical and echocardiographic parameters according to gender in patients with non-obstructive HCM and evaluated the impact of gender on HF presentation and cardiovascular (CV) outcomes in this population. We investigated 202 consecutive patients with non-obstructive HCM. Clinical parameters and conventional echocardiographic measurements including tissue Doppler measurements were evaluated and compared according to gender. Additionally, left ventricular (LV) deformation was assessed with global longitudinal strain (GLS) utilizing 2D speckle tracking software. Of the 202 patients (age  = 63 ± 14 years, male: female = 141: 61), 51 patients (24.8%) presented with HF and female patients had HF more frequently (52.5% vs. 12.8%,P <  0.001). Females were older, had a higher prevalence of atrial fibrillation, had increased left atrial volume (LAV), and a higher ratio of early diastolic mitral inflow to early annular velocity (E/e′) than males (70 ± 12 years vs. 59 ± 14 years,P <  0.001 for age; 51.4 ± 19.3 mL/m2 vs. 40.0\(\pm\) 13.4  mL/m2,P <  0.001 for indexed LAV; 17.2\(\pm\) 6.0 vs. 13.0\(\pm\) 4.3, P  <  0.001 forE/e′). While LV ...
Source: Heart and Vessels - Category: Cardiology Source Type: research