Immunogenicity and Safety of the M72/AS01E Candidate Vaccine Against Tuberculosis: A Meta-Analysis

Conclusion: The M72/AS01E vaccine against TB is safe and effective. Although the vaccine is associated with a mild adverse reaction, it is promising for the prevention of TB in healthy adults. Keywords: vaccine, tuberculosis, M72/AS01E, immunogenicity, safety
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at prese...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Discussion Human trafficking is estimated to be the second largest criminal activity in the world after illegal arms trafficking. It affects all nations with an estimated 27 million people of all ages worldwide but only a small number are identified. It is defined by the United Nations as “the recruitment, transfer, harboring, or receipt of persons by means of threat or use of force or other forms of coercions, abduction, fraud, deception, the abuse of power, or a position of vulnerability to achieve the consent of a person, having control over another person, for the purpose of exploitation.” It includes comme...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
​BY GREGORY TAYLOR, DO; DAWN ZELENKA-JOSHOWITZ, DO; &ANDREW TAECKER, DOA 34-year-old man presented with intermittent fever and body aches for 10 days. He had been visiting family in India, and the symptoms began when he returned home. His fever had been as high as 104°F, and he was experiencing nausea, two episodes of bilious emesis, body aches, nonspecific abdominal pain, and multiple episodes of watery, nonbloody diarrhea.He said he knew of no tuberculosis exposure or ill contacts, and he was current on his routine influenza and hepatitis A vaccines. His temperature was 101.4°F (he had taken acetaminophen t...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury.FundingBill &Melinda Gates Foundation.
Source: The Lancet - Category: General Medicine Source Type: research
CONCLUSION: There are differences between clinician-reported and patient-reported RFVs to primary care, as well as between developed and developing countries. The results of our review are useful for the development of primary care guidelines, the allocation of resources, and the design of training programs and curricula. PMID: 30429181 [PubMed - in process]
Source: Canadian Family Physician Medecin de Famille Canadien - Category: Primary Care Authors: Tags: Can Fam Physician Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with ...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
I treat a lot of different kinds of chronic pain at my clinic. The patients most desperate for relief are the migraine sufferers. If you get migraines, you know they can knock you out for days at a time. The World Health Organization says migraines are to blame for more lost years of healthy life than multiple sclerosis, epilepsy, ovarian cancer and tuberculosis combined.1 But mainstream medicine knows very little about the cause of migraines or how to treat them. Most doctors prescribe Imitrex. That’s a drug to help relieve headaches, pain, nausea, and sensitivity to light and sound.  But Imitrex can actually ...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Brain Health Men's Health Women's Health Source Type: news
Conclusions:This case highlights how Lyme disease should be considered in the differential diagnosis for multiple cranial neuropathies. Further, as prior case reports of CNS Lyme patients have shown polyclonal and monoclonal lymphocyte expansion, this case demonstrates the diagnostic uncertainty regarding whether flow cytometry reflects a reactive process to infection or a new lymphoma. Treatment with antibiotics and clinical improvement helped to clarify the etiology in this case.Disclosure: Dr. Perrone has nothing to disclose. Dr. Xu has nothing to disclose. Dr. Ganguly has nothing to disclose. Dr. Kurowski has nothing t...
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research
CONCLUSION: Young females with abdominopelvic mass, ascites, a positive family history for tuberculosis and high serum cancer antigen 125, should always raise suspicion of tuberculosis especially in a limited resource country. A laparoscopy combined with peritoneal biopsy should be performed to confirm the diagnosis as this could lead to a prevention of unnecessary laparotomies. PMID: 28173770 [PubMed - in process]
Source: Pain Physician - Category: Anesthesiology Authors: Tags: BMC Infect Dis Source Type: research
Conclusion Our interim results on safety and effectiveness of bedaquiline-containing regimens in multidrug and extensively drug-resistant tuberculosis (M/XDR-TB) patients are encouraging. They will add value to understanding role and place of this new anti-TB drug in M/XDR-TB treatment.
Source: International Journal of Mycobacteriology - Category: Infectious Diseases Source Type: research
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