2,2'-Biphenol/B(OH)3 Catalyst System for Nazarov Cyclization.

2,2'-Biphenol/B(OH)3 Catalyst System for Nazarov Cyclization. Chem Pharm Bull (Tokyo). 2019;67(9):1019-1022 Authors: Sugimoto K, Oshiro M, Hada R, Matsuya Y Abstract A novel catalyst system-a combination of the readily available 2,2'-biphenol with the inexpensive, nontoxic, and eco-friendly B(OH)3-promoted the Nazarov cyclization of activated and inactivated divinyl ketones to afford the corresponding cyclopentenones up to 96% yield under, in a cis-selective manner. Compared with the conventional harsh conditions with hazardous reagents, user-friendly method was established with bench-stable and easy-to-handle reagents. PMID: 31474725 [PubMed - in process]
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research