Early Detection of Multiorgan Light-Chain Amyloidosis by Whole-Body 18F-Florbetapir PET/CT

Conclusion: 18F-florbetapir PET/CT detected widespread organ amyloid deposition in subjects with both active AL and AL hematologic remission. In most instances, amyloid deposits in the various organs were not associated with clinical symptoms and, thus, were unrecognized. Early recognition of systemic organ involvement may help tailor treatment, and noninvasive monitoring of organ-level disease may guide management with novel fibril-resorbing therapies.

Source: Journal of Nuclear Medicine - September 2, 2019 Category: Nuclear Medicine Authors: Ehman, E. C., El-Sady, M. S., Kijewski, M. F., Khor, Y. M., Jacob, S., Ruberg, F. L., Sanchorawala, V., Landau, H., Yee, A. J., Bianchi, G., Di Carli, M. F., Falk, R. H., Hyun, H., Dorbala, S. Tags: Clinical Source Type: research