Collagenase Clostridium Histolyticum Injection for Dupuytren Contracture: 2-Year Follow-up.

Collagenase Clostridium Histolyticum Injection for Dupuytren Contracture: 2-Year Follow-up. Clin Orthop Surg. 2019 Sep;11(3):332-336 Authors: Nayar SK, Pfisterer D, Ingari JV Abstract Background: Dupuytren disease is characterized by the development of palmar fibrous tissue that can lead to fixed flexion contracture (FFC) and contribute to functional loss of the involved digits. Our goal was to investigate rates of contracture resolution and recurrence in patients who underwent enzymatic fasciotomy for Dupuytren contracture consisting of collagenase clostridium histolyticum (CCH) injection followed by passive manipulation combined with splinting and home-based therapy. Methods: We prospectively enrolled 34 patients (44 metacarpophalangeal [MCP] and 33 proximal interphalangeal [PIP] joints) treated by one orthopaedic hand surgeon between November 2010 and November 2014. On day 1, CCH was injected into a palpable fibrous cord of the involved fingers. The next day, the finger was passively extended to its maximal corrective position. FFC was measured for each joint before injection and immediately after manipulation. Patients were instructed to wear an extension splint at night and perform stretching exercises at home and were re-evaluated at 6 weeks, 4 months, 1 year, and 2 years. Resolution was defined as improvement of contracture to ≤ 5° of neutral. Recurrence was defined as an increase in FCC of ≥ 20° after treatment. Results: Imme...
Source: Clinics in Orthopedic Surgery - Category: Orthopaedics Tags: Clin Orthop Surg Source Type: research

Related Links:

[Dupuytren´s Disease in an Infant]. Handchir Mikrochir Plast Chir. 2020 Jan 22;: Authors: Kleinsorgen MCV, Juras S, Stoyanova Z, Brenner P, Benatar N PMID: 31968359 [PubMed - as supplied by publisher]
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research
Nature Reviews Rheumatology, Published online: 24 December 2019; doi:10.1038/s41584-019-0363-yStromal–immune cell crosstalk deciphered in Dupuytren disease
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research
Previous studies indicate that patients with a more negative perception of their illness tend to respond less favorably to treatment, but little is known about whether illness perceptions differ based on the type of hand or wrist conditions. Therefore, we compared illness perceptions between patients scheduled to undergo surgery for 4 illnesses in hand surgery: carpometacarpal osteoarthritis (CMC OA), Dupuytren disease, carpal tunnel syndrome (CTS), and trigger finger syndrome (TFS). We hypothesized there would be differences in illness perception between these patient groups.
Source: The Journal of Hand Surgery - Category: Surgery Authors: Tags: Scientific Article Source Type: research
Publication date: Available online 24 October 2019Source: Joint Bone SpineAuthor(s): Maeva Ferrari, Henri Lellouche, Eric Roulot, Alain Yelnik, Thomas Bardin, Philippe Orcel, Pascal Richette, Johann Beaudreuil
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Dupuytren's disease can have a significant impact on the daily lives of patients. Traditionally, treatment focused on surgical correction, but advances in rheumatic pharmacology and surgical techniques have opened up a wider scope of management options. Here the authors give a background of the disease and its treatment, while providing evidence for a link with Peyronie's disease.
Source: Trends in Urology and Men's Health - Category: Urology & Nephrology Authors: Tags: New approaches Source Type: research
Authors: Zachrisson A, Sörensen AI, Strömberg J Abstract Needle fasciotomy (NF) is a minimally invasive treatment option for Dupuytren contractures, but long-term results have indicated a high recurrence rate. This prospective study was initiated to monitor the introduction of NF in a context where limited fasciectomy had been the only treatment option, and to investigate the long-term results. The inclusion criterion was a palpable cord with a Metacarpophalangeal (MCP) and/or Proximal interphalangeal (PIP) contracture in one or more fingers. Fifty-eight fingers in 42 patients (40 male and 2 female with a...
Source: Journal of Plastic Surgery and Hand Surgery - Category: Surgery Tags: J Plast Surg Hand Surg Source Type: research
We describe a technique to improve visualization and isolation of Dupuytren cords using a tongue depressor.
Source: Techniques in Hand and Upper Extremity Surgery - Category: Surgery Tags: Techniques Source Type: research
Conditions:   Dupuytren's Disease;   Surgical Incision Intervention:   Procedure: Surgical treatment Sponsors:   Ramsay Générale de Santé;   Dr ROULOT Recruiting
Source: - Category: Research Source Type: clinical trials
More News: Dupuytren's Contracture | Orthopaedics