Left congenital diaphragmatic hernia-associated musculoskeletal deformities

ConclusionAlthough there was a trend towards an increased risk of the pectus deformity and scoliosis in patients repaired with muscle flap, it did not reach statistical significance. There is a correlation between musculoskeletal deformities and the severity of the CDH.
Source: Pediatric Surgery International - Category: Surgery Source Type: research

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This article is part of a Special Issue entitled: GSK-3 and related kinases in cancer, neurological and other disorders edited by James McCubrey, Agnieszka Gizak and Dariusz Rakus.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Publication date: Available online 21 January 2020Source: Life SciencesAuthor(s): Zhi-min Zeng, Hai-yang Du, Le Xiong, Xiao-li Zeng, Peng Zhang, Jing Cai, Long Huang, An-wen LiuAbstractAimsMicrovascular endothelial cell dysfunction is a leading cause of radiation-related heart disease (RIHD). BRCA1 plays an important role in DNA damage repair. The study aims to explore the effect of BRCA1 in endothelial cells involved in RIHD.Materials and methodsBRCA1 and p21 expression were detected in human umbilical vein endothelial cells (HUVECs) and in mouse heart tissue after irradiation exposure. The effects of BRCA1 on cell prolif...
Source: Life Sciences - Category: Biology Source Type: research
ConclusionsStriking differences in the relative numbers of unruptured AAA repairs and in the population characteristics in various districts of the country point to the possibility of different health needs in the regions and variations in standards of care.
Source: Advances in Medical Sciences - Category: Biomedical Science Source Type: research
Conclusion: Collectively, our results demonstrate that homozygous deletion of miR-17-92 cluster in mouse pancreatic beta-cells promotes the development of experimental diabetes, indicating that miR-17-92 cluster may be positively related to beta-cells restoration and adaptation after streptozotocin-induced damage.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Drypetes klainei Pierre ex Pax is used in Cameroon by Baka people in the wound healing process and for the treatment of burns. In a previous paper we demonstrated the ability of both water (WE) and defatted methanol (DME) extracts to accelerate scratch wound closure in fibroblast cultures, thus validating the traditional use of D. klainey stem bark in the treatment of skin lesions. In this work we carried out a bioassay-guided fractionation of the most active DME, which exhibited in vitro efficacy in accelerating wound healing process, in order to isolate and identify the compound/s responsible for the assessed biological ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Source: Clinical Epidemiology - Category: Epidemiology Tags: Clinical Epidemiology Source Type: research
ConclusionOverall, infants with a RCDH compared to those with a LCDH had greater long-term morbidity, but not if they had undergone FETO.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
Eur J Pediatr Surg DOI: 10.1055/s-0039-1687867 Background Repair of large congenital diaphragmatic hernias (CDHs) is challenging. As primary repair is not always feasible, patches are commonly used. An alternative treatment is split abdominal wall muscle flap repair, which uses vascularized autologous tissue. The aim of this study was to analyze the long-term outcome of large CDH defects undergoing split abdominal wall muscle repair. Materials and Methods This is a retrospective review (2003–2016) of large CDH treated by split abdominal wall muscle flap repair. Results In a total of 107 CDH pa...
Source: European Journal of Pediatric Surgery - Category: Surgery Authors: Tags: Original Article Source Type: research
European J Pediatr Surg Rep 2018; 06: e100-e103 DOI: 10.1055/s-0038-1675377Lung hypoplasia and pulmonary hypertension (PH) in association with congenital diaphragmatic hernia (CDH) may cause fatal respiratory failure. Lung transplantation (Ltx) may represent an option for CDH-related end-stage pulmonary failure. The aim of this study is to report a patient with CDH who underwent Ltx or combined heart-lung transplantation (H-Ltx). Our patient was born at 33 weeks of gestation, with a prenatally diagnosed isolated left CDH. Twenty-four hours after birth, she underwent surgical repair of a type D defect (according to the CDH ...
Source: European Journal of Pediatric Surgery Reports - Category: Surgery Authors: Tags: Case Report Source Type: research
Conclusion: Infants with a right sided CDH do not suffer greater mortality, but greater long term morbidity; these results are important for counselling of parents.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Neonatology and Paediatric Intensive Care Source Type: research
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