Is it possible to evaluate true prophylactic efficacy of antidepressants in severely ill patients with recurrent depression? Lessons from a placebo-controlled trial. The fifth trial of the Danish University Antidepressant Group (DUAG-5)

Conclusions: The high risk of drop out prior to randomisation among the eligible patients was presumably caused by an interaction between the study design and the study population. The findings suggest that long-term trial designs interposing a drug-free period prior to randomisation are not feasible and recommendable in severely ill patients.

http://www.jad-journal.com/article/PIIS0165032712008427/abstract?rss=yes

Source: Journal of Affective Disorders - May 15, 2013 Category: Neurology Authors: Rasmus W. Licht, on behalf of the Danish University Antidepressant Group Tags: Research reports Source Type: research