A DONOR PaO2/FiO2 LESS THAN 300 MMHG DOES NOT DETERMINE GRAFT FUNCTION OR SURVIVAL AFTER LUNG TRANSPLANTATION

A donor arterial PO2/FiO2 (P/F ratio) less than the 300 threshold would frequently result in either exclusion of the donor or placement of the lungs on ex-vivo lung perfusion (EVLP). The aim was to investigate the veracity of the P/F ratio threshold of 300 for donor lung acceptability.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research

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Abstract Although lung transplant remains the only option for patients with end-stage lung failure, short preservation times result in an inability to meet patient demand. Successful cryopreservation may ameliorate this problem; however, very little research has been performed on lung cryopreservation due to the inability to prevent ice nucleation or growth. Therefore, this research sought to characterize the efficacy of small-molecule ice recrystallization inhibitors (IRIs) for lung cryopreservation given their well-documented ability to control ice growth. Sprague-Dawley heart-lung blocks were perfused at room t...
Source: Cryobiology - Category: Biology Authors: Tags: Cryobiology Source Type: research
To match clinical outcomes of heart transplantation against histopathological and ultrastructural characteristics of marginal grafts preserved by cold storage or ex vivo normothermic perfusion.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Because of the high demand of organs, the usage of marginal grafts has increased. These marginal organs have a higher risk of developing ischemia-reperfusion injury, which can lead to posttransplant complications. Ex situ machine perfusion (MP), compared with the traditional static cold storage, may better protect these organs from ischemia-reperfusion injury. In addition, MP can also act as a platform for dynamic administration of pharmacological agents or gene therapy to further improve transplant outcomes. Numerous therapeutic agents have been studied under both hypothermic (1–8°C) and normothermic settings. H...
Source: Transplantation - Category: Transplant Surgery Tags: Reviews Source Type: research
This review article focuses on current clinical outcomes with novel perfusion strategies in organ transplantation. Broadly, these approaches can be divided into in situ regional perfusion in the donor and ex situ machine perfusion of individual organs. In both settings, hypothermic and normothermic techniques are in clinical use. Evidence from full text articles, abstracts, and data presented at scientific meetings has been considered. Animal studies have been excluded. The review focuses on kidney, liver, pancreas, heart, and lungs. The level of evidence ranges from quasi-experimental work in human pancreas to multiple me...
Source: Transplantation - Category: Transplant Surgery Tags: Reviews Source Type: research
Conclusions. During EVLP, CyA administration can have a preconditioning effect through both its anti-inflammatory and mitochondrial protective properties, leading to improved lung graft preservation, which may result in enhanced graft quality after transplantation.
Source: Transplantation - Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Donation after circulatory death (DCD) heart transplantation is gaining widespread acceptance as an additional pathway for donor heart procurement, with excellent short- and mid-term results reported by high-volume centres in Australia and the UK [1, 2]. Due to the obligatory warm ischemic time (WIT) to which all DCD allografts are exposed, the establishment of the first successful adult DCD with distant procurement program in 2014 was dependent on both the development of pharmacological conditioning agents to mitigate myocardial injury, as well as an ex-situ perfusion system to minimise ongoing ischemia and provide a plat...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research Correspondence Source Type: research
Donation after circulatory death (DCD) heart transplantation is gaining widespread acceptance as an additional pathway for donor heart procurement, with excellent short- and mid-term results reported by high-volume centers in Australia and the United Kingdom.1,2 Because of the obligatory warm ischemic time to which all the DCD allografts are exposed, the establishment of the first successful adult DCD with distant procurement program in 2014 was dependent on both the development of pharmacologic conditioning agents to mitigate myocardial injury and an ex situ perfusion system to minimize ongoing ischemia as well as provide...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: RESEARCH CORRESPONDENCE Source Type: research
Heart transplantation is limited by the scarcity of suitable donors. Patients with advanced biventricular failure may require biventricular support to provide optimal cardiac output and end-organ perfusion. We highlight the outcomes of using the HeartWare HVAD System (HVAD) in a biventricular configuration.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: ORIGINAL CLINICAL SCIENCE Source Type: research
Heart transplant is limited by the scarcity of suitable donors. Patients with advanced biventricular failure may require biventricular support to provide optimal cardiac output and end organ perfusion. We highlight the outcomes of using the HeartWare ™ HVAD™ System in a biventricular configuration.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Authors: Ghali MGZ, Stewart R, Ghali GZ, Blitzer W Abstract Facile identification of cardiac allograft vasculopathy (CAV), extensively prevalently identifiable across recipients of cardiac explanted allografts, has proven challenging using non-invasive modalities exclusively. We consequently sought to evaluate diagnostic precision and accuracy of two-dimensional speckle tracking echocardiography (2D-STE) to the end of detecting international society heart &lung transplantation stage III graft vasculopathy (ISHLT-CAV3) in individuals having received cardiac allografts by the meritorious pre-mortem scripted or ve...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
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