Monoterpenoid indole alkaloids from the bark of Melodinus henryi.

Monoterpenoid indole alkaloids from the bark of Melodinus henryi. Fitoterapia. 2019 Aug 30;:104354 Authors: He J, Zhang FL, Li ZH, Yang HX, Shao Q, Feng T, Liu JK Abstract Four new alkaloids, melodinines W1-W4 (1-4), together with twenty one known alkaloids (5-25) were isolated from Melodinus henryi. The structures with absolute configurations were elucidated by extensive MS and NMR spectroscopic methods, as well as the single crystal X-ray diffraction and ECD calculations. All compounds were evaluated for their cytotoxicities to five human cancer cell lines. Many compounds showed certain cytotoxicities to five human cancer cell lines with an IC50 range of 1.4-29.4 μM. PMID: 31473334 [PubMed - as supplied by publisher]
Source: Fitoterapia - Category: Biochemistry Authors: Tags: Fitoterapia Source Type: research