A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue–resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1–mediated proliferation and activation of LFA-1–expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.

Source: The Journal of Experimental Medicine - September 1, 2019 Category: Internal Medicine Authors: Rana, B. M. J., Jou, E., Barlow, J. L., Rodriguez-Rodriguez, N., Walker, J. A., Knox, C., Jolin, H. E., Hardman, C. S., Sivasubramaniam, M., Szeto, A., Cohen, E. S., Scott, I. C., Sleeman, M. A., Chidomere, C. I., Cruz Migoni, S., Caamano, J., Jorgensen, Tags: Brief Definitive Reports Source Type: research