Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses
This study identifies a novel primary immunodeficiency, clarifying the contribution of IL-6 to the phenotype of patients with mutations in IL6ST, STAT3, and ZNF341, genes encoding different components of the IL-6 signaling pathway, and alerts us to the potential toxicity of drugs targeting the IL-6R.
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Spencer, S., Köstel Bal, S., Egner, W., Lango Allen, H., Raza, S. I., Ma, C. A., Gürel, M., Zhang, Y., Sun, G., Sabroe, R. A., Greene, D., Rae, W., Shahin, T., Kania, K., Ardy, R. C., Thian, M., Staples, E., Pecchia-Bekkum, A., Worrall, W. Tags: Immunodeficiency Brief Definitive Reports Source Type: research
More News: Eczema | Genetics | Immunotherapy | Internal Medicine | Primary Immunodeficiency Disease | Study | Toxicology