Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses

This study identifies a novel primary immunodeficiency, clarifying the contribution of IL-6 to the phenotype of patients with mutations in IL6ST, STAT3, and ZNF341, genes encoding different components of the IL-6 signaling pathway, and alerts us to the potential toxicity of drugs targeting the IL-6R.
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Tags: Immunodeficiency Brief Definitive Reports Source Type: research