Use of carbon monoxide breath test to assess red blood cell lifespan in newly diagnosed multiple myeloma patients
To clarify the role of red blood cell (RBC) lifespan in anemia of multiple myeloma (MM), RBC
lifespan was detected in 40 newly diagnosed MM patients by measuring exhaled endogenous carbon
monoxide concentration. Mean RBC lifespan was significantly reduced in MM patients (63 ± 23 d) than
healthy controls (116 ± 17 d). RBC lifespan in MM patients without anemia (78 ± 21 d) was also
significantly lower than for healthy controls. RBC lifespan in MM patients with anemia (52 ± 18 d)
was significantly lower than those without. Besides, RBC lifespan in MM patients with renal
insufficiency (50 ± 16 d) was lower than those without (66 ± 23 d). RBC lifespan was significantly
negatively correlated with % reticulocytes, erythropoietin concentration, % clonal plasma cells, β
2-microglobulin (MG) level, and creatinine level. Receiver operator characteristics curve was used
to determine a cut-off point (61 d) to predict effect of RBC lifespan on chemotherapy. Overall
response rates were s...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Yanfang Wang, Zhenhao Zhang, Yan Liu, Hongmei Jing, Xiaoyan Ke and Fei Dong Source Type: research