Cancers, Vol. 11, Pages 1291: Cancers after Chornobyl: From Epidemiology to Molecular Quantification

Cancers, Vol. 11, Pages 1291: Cancers after Chornobyl: From Epidemiology to Molecular Quantification Cancers doi: 10.3390/cancers11091291 Authors: Dimitry Bazyka Natalya Gudzenko Iryna Dyagil Iryna Ilienko David Belyi Vadim Chumak Anatoly Prysyazhnyuk Elena Bakhanova An overview and new data are presented from cancer studies of the most exposed groups of the population after the Chornobyl accident, performed at the National Research Center for Radiation Medicine (NRCRM). Incidence rates of solid cancers were analyzed for the 1990–2016 period in cleanup workers, evacuees, and the general population from the contaminated areas. In male cleanup workers, the significant increase in rates was demonstrated for cancers in total, leukemia, lymphoma, and thyroid cancer, as well as breast cancer rates were increased in females. Significantly elevated thyroid cancer incidence was identified in the male cleanup workers cohort (150,813) in 1986–2012 with an overall standardized incidence ratio (SIR) of 3.35 (95% CI: 2.91–3.80). A slight decrease in incidence rates was registered starting at 25 years after exposure. In total, 32 of 57 deaths in a group of cleanup workers with confirmed acute radiation syndrome (ARS) or not confirmed ARS (ARS NC) were due to blood malignancies or cancer. Molecular studies in cohort members included gene expression and polymorphism, FISH, relative telomere length, immunophenotype, micronuclei te...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research