The combination of endobronchial elastography and sonographic findings during endobronchial ultrasound ‐guided transbronchial needle aspiration for predicting nodal metastasis

ConclusionThe combination of elastography and sonographic findings showed good sensitivity and a high negative predictive value, which may facilitate selecting the most suspicious lymph nodes for biopsy.Key pointsSignificant findings of the study.The combination of endobronchial elastography and sonography resulted in a higher diagnostic yield than either modality alone for predicting benign and malignant lymph nodes in patients with lung cancer.What this study adds.The combination of endobronchial elastography and sonography will help clinicians identify the most suspicious lymph nodes for puncturing during EBUS ‐TBNA, which may improve the efficiency of EBUS‐TBNA.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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CONCLUSIONS: Our study supports the use of this minimally invasive technique for paraesophageally locatedlung tumors and demonstrates that EUS-FNA is safe and has an excellent diagnostic yield. PMID: 31765444 [PubMed - in process]
Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is highly accurate in diagnosing mediastinal lymphadenopathies of lung cancer and benign disorders. However, the utility of EBUS-TBNA in the diagnosis of mediastinal lymphomas is unclear. So, in this study, we evaluate to determine the diagnositic accuracy of EBUS-TBNA in patients with lymphoma and the factors affecting the diagnosis of lymphoma. Between May 2009 and May 2017, EBUS-TBNA database was analyzed retrospectively. A total of 131 lymph nodes were evaluated in 65 patients pathologically diagnosed lymphoma. The diagnosis rates to subtype o...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional pulmonology Source Type: research
Conclusion: The Flex 19G EBUS-TBNA needle was safely used in this study. However, the efficacy was similar to the 21G needle.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interventional pulmonology Source Type: research
The objective was to evaluate the diagnostic value of endobronchial-ultrasound-guided transbronchial-needle-aspiration (EBUS-TBNA) from tumor and lymph nodes and ctDNA analysis compared to endobronchial forceps-biopsy (FB).30 consecutive central lung cancer subjects (10 female, median age 66, 29 current/ex-smokers) with suspected exophytic lung cancer were included.The sequence of FB and EBUS-TBNA procedures for tissue sampling was randomized. Mediastinal lymph node tissue and blood plasma was sampled additionally. PD-L1 expression level was quantified by percent of tumor cells. Mutational analysis was performed by massive...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
Conclusion: Waste material obtained during EBUS contains diagnostic material in the majority of cases, and in our cohort contained at least as much material as the corresponding EBUS-TBNA needle sample in 50% of samples. This is important when considering the rising amount of tissue required by oncologists for molecular testing.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
EBUS-TBNA (Endobronchial ultrasound) is a minimally invasive procedure that has gained considerable importance in recent years, especially for the evaluation of mediastinal lymph nodes in lung cancer staging.Elastography is a ultrasound technique able to provide during EBUS evaluations on the rigidity of a tissue, and / or lymph node adjacent to the bronchial tree.Two types of elastography are available: strain elastography(SE) and Shear wave elastography(SWE).From July 2017 to Dicember 2018 100 patients with lymph node disease associated with or without lung lesions were selected and 130 lymph nodes were sampled with EBUS...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) is used for both the staging and diagnosis of suspected malignant mediastinal lesions, as well as for diagnosing benign mediastinal lesions.Mediastinal lymph node characteristics like morphology, size and vascularization can be observed, but their relationship with malignancy is controversial.The aim of this study was to analyze the relationship between lymph node characteristics and malignancy in a real-world setting of a Central University Hospital.A retrospective cohort analysis of lymph nodes submitted to EBUS-TBNA between January 2016 and Dec...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
Introduction: The EBUS-TBNA is a minimally invasive technique widely used in the diagnosis, staging and immunohistochemistry analysis of lung cancer.1PDL-1 is a checkpoint on NSCLC that can be targeted with immunotherapy.2Routine PDL-1 testing was introduced at Oxford University Hospital NHS Foundation Trust (OUHFT) in 2017 and it is unclear if EBUS-TBNA provides adequate tissue for testing. In our current practice at the OUHFT, all NSCLC cases (Squamous Cell Lung Carcinoma and Lung Adenocarcinoma) identified on cytopathology are subsequently tested for PDL-1 tumour percentage score (TPS). The aim of this study was to see ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
Conclusion: We conclude that it is feasible for pulmonologist to perform FLB immediately after endoscopy as a combined triple approach in a fast-track workup of suspected lung cancer.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
Conclusion: The preliminary diagnoses (ROSE) are concordant with the final diagnoses in a high percentage. Consequently, clinical decisions based on the ROSE can be taken with confidence.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Source Type: research
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