Generation of an induced pluripotent stem cell line (SDQLCHi008-A) from a patient with ASD and DD carrying an 830 kb de novo deletion at chr7q11.22 including the exon 1 of AUTS2 gene

Publication date: Available online 31 August 2019Source: Stem Cell ResearchAuthor(s): Xiaomeng Yang, Tiancheng Zhou, Haiyan Zhang, Yue Li, Rui Dong, Ning Liu, Guangjin Pan, Yi Liu, Zhongtao GaiAbstractAn induced pluripotent stem cell (iPSC) line was generated from human urine-derived cells of a 4 year-old boy with autism spectrum disorder(ASD) and developmental delay (DD) carrying a 830 kb de novo deletion at chromosome 7q11.22 disrupting the first exon and promoter region of AUTS2. The iPSC retained the original deletion of AUTS2, and had a normal karyotype, express pluripotency markers and bear differentiation potential in vitro.
Source: Stem Cell Research - Category: Stem Cells Source Type: research