The Pitfall of Utilizing a Commercial Biochemical Yeast Identification Kit to Detect. Candida auris.
The Pitfall of Utilizing a Commercial Biochemical Yeast Identification Kit to Detect. Candida auris. Ann Clin Lab Sci. 2019 Sep;49(4):546-549 Authors: Ding CH, Situ SF, Steven A, Razak MFA Abstract Candida auris is an emerging pathogenic yeast responsible for nosocomial infections with high mortality, on a global scale. A 65-year-old woman with hypovolemic shock and severe metabolic acidosis was intubated and admitted to the intensive care unit (ICU). Shortly after admission, she developed ventilator-associated pneumonia caused by multidrug-resistant Acinetobacter baumannii, which necessitated treatment with high-dose ampicillin-sulbactam. Two weeks later, a yeast was cultured from her blood. It formed pale pink colonies on CHROMagar Candida medium and produced predominantly oval budding yeast cells with the occasional rudimentary pseudohyphae on cornmeal agar. ID 32 C identified the yeast as Candida sake However, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and sequencing of the D1/D2 region of the 28S rRNA gene identified the yeast as C. auris. PMID: 31471347 [PubMed - in process]
We describe a case of a 59-year-old male with esophageal adenocarcinoma undergoing chemotherapy presenting with a right upper lobe necrotizing pneumonia secondary to B. cereus with consequent massive hemoptysis.
Updated guidelines on community-acquired pneumonia focus on reducing inappropriate use of antibiotics and emphasize the need for more research on diagnostics and therapeutics.Medscape Medical News
In conclusion, to best of our knowledge these findings are the first report of isolation of 4-bromophenol and Bis (2-ethylhexyl) phthalate from genus Nocardiopsis, thus suggesting that rare actinomycetes are promising source of therapeutically important bioactive metabolites.
ConclusionThe draft genome sequence reported here will lay the foundation for future research on antimicrobial resistance and pathogenic mechanisms in K. quasipneumoniae subsp. quasipneumoniae and also will promote comparative analysis with genomic features among different sources of clinically important multidrug-resistant strains.
ConclusionIt is concluded that NIT resistance in the studied NIT-RE. coli isolates was mainly mediated by nfsA and nfsB alterations.
Authors: Bassetti M, Giacobbe DR, Peghin M, Irani P Abstract Introduction: Antimicrobial resistance poses a substantial threat to global public health concern, since it decreases the probability of effectively treating an infection and increases risk of morbidity and mortality. Areas covered: In this review, the authors discuss the advantages and disadvantages of classical and novel trial designs for evaluating novel antibiotics for infections due to multidrug-resistant organisms (MDRO). An inductive literature search was performed using different keywords pertinent to the reviewed topics. Expert opinion: The need ...
ConclusionIn this meta-analysis, ibrutinib was associated with significantly higher risk of infections in patients with B-cell malignancies. Occurrence of major individual subtypes was not different between groups, possibly due to inconsistent reporting across studies.
Conclusions Receipt of nerve blocks for hip fracture surgery is associated with decreased length of stay and health system costs, although small effect sizes may not reflect clinical significance for length of stay.
Publication date: Available online 15 October 2019Source: Anaesthesia &Intensive Care MedicineAuthor(s): Russell AllanAbstractCommunity-acquired pneumonia (CAP) is a common inflammatory process contained within the lung tissue in response to infection with non-hospital pathogens. Full resolution usually occurs with appropriate antimicrobial therapy. A significant proportion of patients develop severe CAP where there is failure to contain the local immune response and these patients may require admission to the intensive care unit (ICU). The CURB-65 severity score is a rapid, objective way of predicting mortality and ca...
ConclusionThese findings might effectively help to avert the severe complications of diabetic foot infections (DFIs) besides our endeavors to find new antimicrobial wound dressings.