Synthesis of amido sulfonamido heteroaromatics under ultrasonication and their antimicrobial activity.

Synthesis of amido sulfonamido heteroaromatics under ultrasonication and their antimicrobial activity. Chem Biodivers. 2019 Aug 30;: Authors: Divya KRG, Teja GL, Yamini G, Padmaja A, Padmavathi V Abstract A convenient and facile methodology for N-sulfonylation of heteroaryl amines with ethyl chlorosulfonylacetate in the presence of dispersed sodium in THF under ultrasonication is reported. The corresponding heteroaryl sulfonamido esters are directly condensed with heteroaryl amines to get amido sulfonamido heteroaromatics in the presence of mild base in THF under ultrasonication. Utilization of easy reaction conditions, shorter reaction times, and isolation of products in high yields under ultrasonication makes this process as an economically viable. The compounds 12c, 12d, 12f and 13f are potential antibacterial agents against B. subtilis and the compounds 12f, 13c and 13f are potential antifungal agents against A. niger. PMID: 31469234 [PubMed - as supplied by publisher]
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research