Human CTLA4-Ig therapy can give false-positive anti-pig antibody results in primates after xenotransplantation.

CONCLUSIONS: pAECs might not be an optimal cell to investigate anti-pig IgG binding when hCTLA4-Ig is administered to the recipient, as a false-positive result may result from hCTLA4-Ig binding to the pAECs. CD3+T cells would be preferable targets (compared to pRBCs) because they express both carbohydrate and MHC class I/II antigens.
PMID: 31472231 [PubMed - as supplied by publisher]

Source: Transplant Immunology - August 27, 2019 Category: Transplant Surgery Authors: Li Q, Yamamoto T, Iwase H, Nguyen HQ, Wang Y, Ayares D, Cooper DKC, Hara H Tags: Transpl Immunol Source Type: research