Quantitative susceptibility mapping in atypical Parkinsonisms

ConclusionQSM could be used for iron quantification of nigral and extranigral structures in all degenerative parkinsonisms and should be tested longitudinally in order to identify early microscopical changes.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research

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In this study, we aimed to investigate an analogous spatial covariance pattern exist in patients with DLB and how it characterize the boundary issues between DLB and PD. Methods: In this study, we prospectively recruited 20 patients with DLB and 20 age/gender matched healthy control subjects to perform FDG PET imaging. 33 patients with PD and 33 age/gender matched healthy control subjects were also enrolled (Scans from these subjects were originally used to identify the PDRP biomarker in Chinese population). DLB-related pattern(DLBRP)was identified in the DLB patients and corresponding control subjects by an automated netw...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research
The diagnosis of Parkinson's disease (PD) relies on the clinical effects of dopamine deficiency, including bradykinesia, rigidity and tremor, usually manifesting asymmetrically. Misdiagnosis is common, due to overlap of symptoms with other neurodegenerative disorders such as multiple system atrophy and progressive supranuclear palsy, and only autopsy can definitively confirm the disease. Motor deficits generally appear when 50–60% of dopaminergic neurons in the substantia nigra are already lost, limiting the effectiveness of potential neuroprotective therapies. Today, we consider PD to be not just a movement disorder...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSION: STS scale on SMWI may serve as a useful imaging biomarker for diagnosis of parkinsonism and disease progression evaluation in PD. PMID: 32380911 [PubMed - as supplied by publisher]
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The J.P. Morgan Healthcare conference runs every year in San Francisco, a big draw for the biotech industry, and many organizations take the opportunity to host events at the same time. Among these, the SENS Research Foundation has for the past few years hosted a pitch day in which biotech companies in the longevity industry, largely startups, present to that portion of the Bay Area investor community interested in funding the treatment of aging as a medical condition. I was there to present on progress at Repair Biotechnologies, and took some notes on the other companies as they talked about their work. Kimera Labs ...
Source: Fight Aging! - Category: Research Authors: Tags: Investment Source Type: blogs
CONCLUSIONS: SWJs in PSP are not mediated by midbrain atrophy. Instead, supratentorial cortical structures located mainly in the temporal lobe appear to be deeply involved in the generation of abnormally high SWJ rates in these patients. Known anatomical connections of the temporal lobe to the superior colliculus and the cerebellum might play a role in SWJ genesis. PMID: 31942756 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
Objective : The process of diagnosing many neurodegenerative diseases, such as Parkinson ’s and progressive supranuclear palsy, involves the study of brain magnetic resonance imaging (MRI) scans in order to identify and locate morphological markers that can highlight the health status of the subject. A fundamental step in the pre-processing and analysis of MRI scans is the identification of the mid-sagittal plane, which corresponds to the mid-brain and allows a coordinate reference system for the whole MRI scan set. Approach : To improve the identification of the mid-sagittal plane we have developed an algorith...
Source: Physiological Measurement - Category: Physiology Authors: Source Type: research
ConclusionSemiquantitative123I-FP-CIT SPECT striatal evaluation combined with SVM represents a promising approach to disentangle PD from non-degenerative conditions and from atypical PS at the early stage.
Source: Journal of Neurology - Category: Neurology Source Type: research
Conclusions: The results of this preliminary multi-center evaluation indicate a value of 18F-PI2620 to diagnose and differentiate suspected PSP patients in vivo. The magnitude of tracer binding between patients seems to be variably expressed but not correlated with disease severity. These results indicate that 18F-PI2620 may show potential as a biomarker to assess tau pathology in PSP patients and that it may be helpful to establish earlier and more reliable diagnosis of PSP.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Brain Imaging Council YIA Symposium Source Type: research
1497Objectives: MIBG cardiac sympathetic imaging has been demonstrated to be promising in differentiating Parkinson’s disease (PD) from other neurodegenerative parkinsonism. Age at onset has an impact on cardiac MIBG uptake in PD, but not in multiple system atrophy (MSA) or progressive supranuclear palsy (PSP). In the present study, we hypothesized that there is an interaction between age at onset and disease group for H/M ratios. Radioactive iodine labeled MIBG cardiac sympathetic imaging is less promising in differentiating PD from other parkinsonism for early-onset patients. Methods: Ninety-two patients with parki...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
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