Quantitative susceptibility mapping in atypical Parkinsonisms

ConclusionQSM could be used for iron quantification of nigral and extranigral structures in all degenerative parkinsonisms and should be tested longitudinally in order to identify early microscopical changes.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research

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ConclusionSemiquantitative123I-FP-CIT SPECT striatal evaluation combined with SVM represents a promising approach to disentangle PD from non-degenerative conditions and from atypical PS at the early stage.
Source: Journal of Neurology - Category: Neurology Source Type: research
Conclusions: The results of this preliminary multi-center evaluation indicate a value of 18F-PI2620 to diagnose and differentiate suspected PSP patients in vivo. The magnitude of tracer binding between patients seems to be variably expressed but not correlated with disease severity. These results indicate that 18F-PI2620 may show potential as a biomarker to assess tau pathology in PSP patients and that it may be helpful to establish earlier and more reliable diagnosis of PSP.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Brain Imaging Council YIA Symposium Source Type: research
1497Objectives: MIBG cardiac sympathetic imaging has been demonstrated to be promising in differentiating Parkinson’s disease (PD) from other neurodegenerative parkinsonism. Age at onset has an impact on cardiac MIBG uptake in PD, but not in multiple system atrophy (MSA) or progressive supranuclear palsy (PSP). In the present study, we hypothesized that there is an interaction between age at onset and disease group for H/M ratios. Radioactive iodine labeled MIBG cardiac sympathetic imaging is less promising in differentiating PD from other parkinsonism for early-onset patients. Methods: Ninety-two patients with parki...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
Conclusions: We successfully developed a 3D deep residual convolutional neural network for automated differential diagnosis of IPD and atypical parkinsonism with excellent performance in diagnostic accuracy. The greatest salience was in expected regions of the basal ganglia, but initial findings also implicate high order visual cortex and prefrontal cortex. The method is currently under detailed assessment in a separate group of several hundred parkinsonian patients, and with emphasis on the interpretation of the saliency maps in diagnosis. [1] Tang et al. Lancet Neuro 2010 [2] Wu et al. SNMMI 2018 [3] Springenberg, J.T., arXiv:1412.6806
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Brain Imaging Reloaded I Source Type: research
This study has investigated the kinematic features of progressive micrographia during a repetitive writing task. Twenty-four PD patients with duration since diagnosis of 10% decrement in letter stroke length. The relationships between dimensional and kinematic features for the control subjects and for PD patients with and without progressive micrographia were studied. Differences between the initial and last letter repetitions within each group were assessed by Wilcoxon signed-rank test, and the Kruskal-Wallis test was applied to compare the three groups. There are five main conclusions from our findings: (i) 66% of PD pat...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Grand Total EEG Score Can Differentiate Parkinson's Disease From Parkinson-Related Disorders Ela Austria Barcelon1,2*, Takahiko Mukaino1, Jun Yokoyama1, Taira Uehara2, Katsuya Ogata2, Jun-ichi Kira1 and Shozo Tobimatsu2 1Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan2Department of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Background: Semi-quantitative electroencephalogram (EEG) analysis is easy to perform and has been used to differentiate dementias, as well ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This study aimed to investigate white matter microstructure alterations by using connectometry in patients with PD-EDS, in comparison to PD-nEDS and healthy individuals. Materials and Methods Participants Participants involved in this research were recruited from Parkinson's Progression Markers Initiative (PPMI, http://www.ppmi-info.org/). The study was approved by the institutional review board of all participating sites in Europe, including Attikon University Hospital (Greece), Hospital Clinic de Barcelona and Hospital Universitario Donostia (Spain), Innsbruck University (Austria), Paracelsus-Elena Clinic Kass...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: [18F]AV ‐1451 tau‐PET measures increase over time in subjects with PSP, but longitudinal [18F]AV ‐1451 measures may not perform as well as rate of midbrain atrophy as biomarkers for PSP clinical trials. © 2018 International Parkinson and Movement Disorder Society
Source: Movement Disorders - Category: Neurology Authors: Tags: Research Article Source Type: research
AbstractPurpose of ReviewDifferential diagnosis of atypical Parkinson syndromes (APS) is difficult as clinical presentations may vary and as there is a strong overlap between disease entities. Aggregations of misfolded and hyperphosphorylated tau proteins are the common denominator of many of these diseases.Recent FindingsSeveral tau targeting positron emission tomography (PET) tracers have been evaluated as possible biomarkers in APS in the recent years. For Parkinson ’s disease, dementia with Lewy bodies, progressive supranuclear palsy, and corticobasal degeneration, promising results have been reported with regard...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
Conclusion D2 antagonism by (-)-eticlopride at high dose (0.03 mg/kg) dramatically increased striatal uptake of [18F]VAT in NHPs, suggesting PET with [18F]VAT provides a useful tool for investigation of dopaminergic modulation on VAChT expression in the brain of living animals. The elevation of striatal [18F]VAT uptake by 0.03 mg/kg (-)-eticlopride might be attributed to the disinhibition of cholinergic transmission by D2 antagonism. Ongoing studies are exploring the impact of D2 agonism on VAChT expression in the NHP brain. These results may help guide future investigation of the effects of dopaminergic drugs on cholinerg...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science III Source Type: research
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