Five 11 α, 12α-epoxy pentacyclic triterpenoid saponins with antithrombus activities from Glechoma longituba.

Five 11α, 12α-epoxy pentacyclic triterpenoid saponins with antithrombus activities from Glechoma longituba. Fitoterapia. 2019 Aug 27;:104345 Authors: Ouyang XL, Mao WH, Wang CG, Pan YM, Liang D, Wang HS Abstract The present study reports the phytochemical investigation of n-butanol-soluble extracts of Glechoma longituba. Five new oleanane-type triterpenoid saponins with an 11α, 12α-epoxy unit, named glechomanosides A - E, were isolated from the n-butanol soluble fraction of G. longituba. Their chemical structures were established using HRESIMS, IR, 1D NMR, and 2D NMR techniques. The compounds were all evaluated for their antithrombus activities by monitoring thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), and antiplatelet aggregation assays. These results suggest that G. longituba might be a candidate plant source of an interesting antithrombotic activity. PMID: 31470063 [PubMed - as supplied by publisher]
Source: Fitoterapia - Category: Biochemistry Authors: Tags: Fitoterapia Source Type: research