Development of bone seeker–functionalised microspheres as a targeted local antibiotic delivery system for bone infections

ConclusionWe report the development and characterisation of a DDS which can release antibiotics in a sustained manner. Surface-grafted alendronate groups enhanced bone affinity of the microsphere construct, resulting in a bone targeting DDS.The Translational Potential of this ArticleThe DDS presented can be loaded with hydrophobic antibiotics, representing a potential, versatile and biodegradable candidate to locally treat bone infection.
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research