Regulation of cellular senescence by retinoid X receptors and their partners
Publication date: Available online 30 August 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): Nadine Martin, Xingjie Ma, David BernardABSTRACTCellular senescence is a response characterized by a stable cell proliferation arrest and a senescence-associated secretory phenotype (SASP) which can be induced by many stresses, including telomere shortening and oncogene activation. Senescence is crucially involved in a variety of physiopathological contexts, such as cancer and aging. Given the fundamental role of this process, senescence needs to be tightly regulated. In the last decade, the key implication of nuclear receptors in cellular senescence has emerged. Here we will review the mechanisms involved in the control of cellular senescence by retinoid X receptors (RXRs) and their partners. We will also present our current knowledge on the regulation of these receptors during senescence and on their potential role in senescence-associated physiopathological conditions.
Publication date: Available online 30 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Kevin C. Lee, Sung-Kiang Chuang
Publication date: Available online 30 May 2020Source: Pharmacological ResearchAuthor(s): Ling Wang, Ke Deng, Liang Gong, Liang Zhou, Sapna Sayed, Huan Li, Qi Sun, Zijie Su, Zhongyuan Wang, Shanshan Liu, Huifang Zhu, Jiaxing Song, Desheng Lu
Publication date: Available online 31 May 2020Source: Pharmacology &TherapeuticsAuthor(s): Jie Yu, Bingling Zhong, Qingwen Xiao, Lida Du, Ying Hou, Hong-Shuo Sun, Jin-Jian Lu, Xiuping Chen
Publication date: Available online 31 May 2020Source: Pharmacology &TherapeuticsAuthor(s): Kevin M. Levine, Kai Ding, Lyuqin Chen, Steffi Oesterreich
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Qi Chen, Huachao Xu, Jiang Zhu, Kehai Feng, Changlu Hu
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Celso Alves, Eurico Serrano, Joana Silva, Carlos Rodrigues, Susete Pinteus, Helena Gaspar, Luis M. Botana, Maria C. Alpoim, Rui Pedrosa
Publication date: Available online 30 May 2020Source: PhytomedicineAuthor(s): Weihuan Huang, Yeyin Liang, Hau Yin Chung, Guocai Wang, Jim Junhui Huang, Yaolan Li
CONCLUSIONS: An approach to standardise current dose modification schemes in young children is proposed. The consented concept takes individual pharmacokinetic characteristics into account and involves adaptation of both the dose and the infusion duration potentially improving the safety of doxorubicin administration. PMID: 32466789 [PubMed - in process]
Osborne H Abstract The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, γ-glutamyl peptides, polyamines, polycationic peptides, and protons. The CaSR plays a critical role in extracellular calcium (Ca2+ o) homeostasis, as demonstrated by the many naturally occurring mutations in the CaSR or its signaling partners that cause Ca2+ o homeostasis disorders. However, CaSR tissue expression in mammals is broad and includes tissues unrelated to Ca2+ o homeostasis, ...
Publication date: Available online 30 May 2020Source: Seminars in Cancer BiologyAuthor(s): María González González, María Laura Gutiérrez, José María Sayagués, Luis Muñoz-Bellvís, Alberto Orfao