Psycholinguistic profile of young adults with Down syndrome

Conclusions and implicationsThe psycholinguistic pattern of young adults with DS is not homogeneous with respect to auditory and visual processing. The profile of specific deficits suggests that the educative support for young adults with DS may need to be specific.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research

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Conclusions and ImplicationsAlthough group differences were not found when considering parent-reported sleep problems, more frequent sleep problems were positively associated with increased forgetting by children with DS relative to those who were TD. Although future experimental work is needed to determine causality, these results suggest that improved sleep in children with DS might reduce forgetting, ultimately improving long-term recall memory.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Abstract People with Down syndrome (DS) show dysfunction of gait, expressed by disturbed character of angular changes and values of the spatiotemporal parameters as compared to the physiological norm. It is known that exercises and various activities have positive effect on balance and gait, but there are only a few scientific proofs concerning above-mentioned in people with DS. Furthermore, the effect of Nordic Walking (NW) training on gait in people with DS is unexplored. We enrolled 22 subjects with DS, aged 25-40 years, with moderate intellectual disability. Participants were randomly divided into 2 groups: NW...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
(University of California - San Francisco) In a surprising finding using the standard animal model of Down syndrome (DS), scientists were able to correct the learning and memory deficits associated with the condition -- the leading genetic cause of cognitive disability and the most frequently diagnosed chromosomal disorder in the US -- with drugs that target the body's response to cellular stresses.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
In this study, we found that the integrated stress response (ISR)—a signaling network that maintains proteostasis—was activated in the brains of DS mice and individuals with DS, reprogramming translation. Genetic and pharmacological suppression of the ISR, by inhibiting the ISR-inducing double-stranded RNA–activated protein kinase or boosting the function of the eukaryotic translation initiation factor eIF2-eIF2B complex, reversed the changes in translation and inhibitory synaptic transmission and rescued the synaptic plasticity and long-term memory deficits in DS mice. Thus, the ISR plays a crucial role ...
Source: ScienceNOW - Category: Science Authors: Tags: Cell Biology, Neuroscience r-articles Source Type: news
MONDAY, Nov. 4, 2019 -- Most people with Down syndrome have dementia by age 55, a new study shows. People with Down syndrome are born with an extra copy of chromosome 21, which often results in developmental disabilities. Surviving to middle age...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Conclusions: Based on the literature assessed, the Timed Up and Go is clinically applicable and reliable across multiple populations. The Timed Up and Go has a wide variety of clinical use making it a diverse measure that should be considered when choosing an outcome an activity based outcome measure. However, there are some limitations in the validity of the utilization of the Timed Up and Go to some populations due to a lack of data and/or poor choice of comparison outcome measures when assessing validity. Additional research is needed for young to middle aged adults. IMPLICATIONS FOR REHABILITATION Outcome measures are ...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
This study is the first to report the presence of defective interhemispheric connectivity at the time of birth in Ts65Dn mice, providing evidence that early therapeutic intervention may be an effective time window for the treatment of Down syndrome.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
AbstractThe aim of this research study was to examine the effects of Assisted Cycling Therapy (ACT) on adaptive/maladaptive behaviors, depression, and self-efficacy in adolescents with Down syndrome (DS). The participants were counterbalanced to either intervention groups of 1) Assisted Cycling Therapy (ACT), in which the participants ’ voluntary pedaling rates were augmented with a motor to ensure the maintenance of 80 rpm or greater 2) Voluntary Cycling (VC), in which participants cycled at their self-selected pedaling rate or 3) No Cycling (NC), in which the participants sat and watched a video. The ACT and V...
Source: Journal of Developmental and Physical Disabilities - Category: Disability Source Type: research
CONCLUSION: The specific tumor profile in DS warrants an adapted screening program for breast, colon, cervical and testicular neoplasia. PMID: 31605815 [PubMed - as supplied by publisher]
Source: European Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Tags: Eur J Med Genet Source Type: research
CONCLUSIONS &IMPLICATIONS: Findings suggest that impairments in a critical pragmatic skill-the ability to repair communication breakdown-show significant change with age across three neurodevelopmental disabilities, with important sex-specific patterns. These developments were often observed in spite of a relative plateau in cognitive and language growth, suggesting that repair skills may be more malleable and therefore an excellent target for intervention. Findings not only inform the nature of pragmatic impairment across groups but also can importantly inform clinical practice, suggesting that clinicians should monit...
Source: International Journal of Language and Communication Disorders - Category: Speech-Language Pathology Authors: Tags: Int J Lang Commun Disord Source Type: research
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