Volumetric investigation of the hippocampus in rat offspring due to diabetes in pregnancy–A stereological study

ConclusionThese data indicate that diabetes during pregnancy has a negative impact on the development of the hippocampus in the rats. These changes in the volume of hippocampal CA1, DG, and subiculum areas might be at the core of underlying neurocognitive and neurobehavioral impairments observed in the children of diabetic mothers.
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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(The Hebrew University of Jerusalem) Pregnant smokers at higher risk for gestational diabetes, Hebrew University study finds.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
AbstractAimsRecent studies have suggested a possible association between microbiota and gestational diabetes (GDM). However, the results are inconsistent. Our objective was to investigate further the relationship between GDM and microbiota and verify the potential microbial marker.MethodsTwo complementary approaches were used for the demonstration. First, we compared the gut microbial composition of 23 GDM patients and 26 non-GDM ethnically Chinese Han pregnant women, by using whole-metagenome shotgun sequencing of their stool samples collected at the third trimester. Second, we used Q-PCR (quantitative polymerase chain re...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
This study aimed to determine, in women with gestational diabetes (GDM), the changes in insulin sensitivity (Matsuda Insulin Sensitivity Index; ISOGTT), insulin response and disposition index (DI) from late pregnancy (34 –37 weeks gestation, T1), to early postpartum (1–5 days, T2) and late postpartum (6–12 weeks, T3). A secondary aim was to correlate the longitudinal changes in maternal lipids, adipokines, cytokines and weight in relation to the changes in ISOGTT, insulin response and DI.MethodsISOGTT, insulin response and DI were calculated at the three time points (T1, T2 and T3) using th...
Source: Diabetologia - Category: Endocrinology Source Type: research
Authors: Güler B, Özler S, Kadıoğlu N, Özkan E, Güngören MS, Çelen Ş Abstract Our aim was to investigate whether Antimullerian Hormone (AMH), complete blood count (CBC), Homeostasis model assessment (HOMA-IR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and weight gain have any diagnostic value for the prediction of cardiovascular disease (CVD) in obese and non-obese pregnant patients. A prospective, case-control study was carried out, including 187 patients (93 obese, and 94 non-obese). CVD risk for each patient was evaluated according to the American College o...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
ConclusionsThe original CANRISK score performed well among young adults, even when compared to a young adult-specific model. We suggest that the cut-point be lowered for young adults and the tool be permitted for use in this age group.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Pregnancy is a time of significant hemodynamic, metabolic, and hormonal stress that can unmask underlying subclinical cardiovascular abnormalities, and pregnancy-related complications may serve as early warning signs for future risk of cardiovascular disease. The increased recognition of these sex-specific risk factors could identify women who may benefit from more intensive risk factor modification to reduce morbidity and mortality later in life. In this review, we describe several pregnancy-related complications that have been associated with the risk of cardiovascular disease, including hypertensive disorders of pregnan...
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
Women who had bariatric surgery between their first and second pregnancies had better pregnancy and birth outcomes, a study found.Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Ob/Gyn & Women ' s Health News Source Type: news
Infants born prematurely were at increased risk of both Type 1 and Type 2 diabetes in ensuing decades.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Diabetes Premature Babies Babies and Infants Pregnancy and Childbirth Source Type: news
Gestational diabetes mellitus (GDM) is a common pregnancy complication. Its etiology remains incompletely understood. Studies in recent years suggest that fetal sex may affect maternal metabolic milieu during pregnancy. We sought to assess whether there is fetal sex dimorphism in the risk factors of GDM. In a prospective pregnancy cohort in Shanghai, China, we studied 2,435 singleton pregnant women without pre-existing diabetes. GDM was diagnosed according to the International Association of Diabetes and Pregnancy Study Groups (IADPSG)' criteria. Log-binomial models were applied to obtain the adjusted relative risk (aRR). ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionIncreased expression levels of KISS1 and KISS1R in case of diabetes mellitus may play a role in the altered placentation process and lead to the development of preeclampsia.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
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