Determination of bone sodium (Na) and Na exchange in pig leg using in vivo neutron activation analysis (IVNAA)

Objective : The locations of sodium (Na) storage and its exchange mechanisms in the body are not
well known. Understanding tissue Na storage and exchange is important for understanding the impact
of Na intake, absorption, and retention on human health, especially on the risk of developing
chronic diseases. The purpose of this study was to investigate the application of a
deuterium –deuterium (DD) neutron generator-based IVNAA system in Na nutrition studies. Approach :
The right legs of two live pigs, one on a low Na diet and one on a high Na diet, both for 14 d, were
irradiated inside a customized irradiation cave for 10  min (45 mSv dose to the leg) and then
measured with a 100% efficient high purity germanium detector (HPGe). The spectra were analyzed to
obtain the net Na counts at different time points. Bone Na concentrations were calculated using the
calibration created with Na bone phantoms. Main results : The results show that the difference in
bone Na to ...

Source: Physiological Measurement - July 31, 2019 Category: Physiology Authors: Mychaela D Coyne, Andrea Lobene, Colby Neumann, Pamela Lachcik, Connie M Weaver and Linda H Nie Source Type: research