Phytochemical content, Antidiabetic, Anticholinergic, Antioxidant Activities of Endemic Lecokia cretica Extracts.

Phytochemical content, Antidiabetic, Anticholinergic, Antioxidant Activities of Endemic Lecokia cretica Extracts. Chem Biodivers. 2019 Aug 29;: Authors: Aras A, Bursal E, Türkan F, Tohma H, Kılıç Ö, Gülçin İ, Köksal E Abstract The aim of this work was to investigate the enzyme inhibition, antioxidant activity, and phenolic compounds of Lecokia cretica (Lam.) DC. Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-glycosidase enzymes were strongly inhibited by the L. cretica extracts. IC 50 values for the three enzymes were found as 3.21 mg/mL, 2.1 mg/mL, and 2.07 mg/mL respectively. Antioxidant activities were examined in both aqueous and ethanol (EtOH) extracts using CUPRAC, FRAP, and DPPH method. Also, the phenolic compounds of the endemic plant were identified and quantified by using HPLC-MS/MS. According to the results, the extracts have remarkable antioxidant activities. The most abundant phenolic acids of L. cretica in EtOH extract were determined as quinic acid (12.76 mg/kg of crude extract), chlorogenic acid (3.39 mg/kg), and malic acid (2.38 mg/kg). PMID: 31465610 [PubMed - as supplied by publisher]
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research