The risk factors for urinary dysfunction after autonomic nerve-preserving rectal cancer surgery: a multicenter retrospective study at Yokohama Clinical Oncology Group (YCOG1307)

AbstractAimThe aim of this retrospective study was to evaluate the frequency and risk factors of urinary dysfunction after autonomic nerve-preserving surgery for rectal cancer.MethodsThis was a retrospective multiinstitution study of 1002 rectal cancer patients conducted between January 2008 and December 2012 in Yokohama Clinical Oncology Group. Patients who had preoperative urinary dysfunction or had not undergone autonomic nerve preservation surgery were excluded. Urinary dysfunction was defined as that with a Clavien-Dindo classification grade ≥ 2. Patient-, tumor-, and surgery-related variables were examined by univariate and multivariate analyses.ResultsA total of 887 patients were analyzed. Postoperative urinary dysfunction was observed in 77 patients (8.8%). A multivariate logistic analysis showed that a tumor location in lower rectum (odds ratio [OR] 2.16; 95% confidence interval [CI] 1.15 –3.71;p = 0.02), tumor diameter ≥ 40 mm (OR 2.07; 95% CI 1.19–4.44;p 
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research

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ConclusionThis is one of the largest studies to date to describe the epidemiology of EoCRC in USA. We found EoCRC to occur predominantly in the Caucasian and female population. EoCRC presented more frequently with left-sided and rectal CRC. We also identified signs/symptoms as well as comorbidities associated with EoCRC. Patients with these features may benefit from earlier screening.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
By just engaging in the basic strategies in the Wheat Belly Total Health, Wheat Belly 10-Day Grain Detox, or Undoctored programs, many mild cases of small intestinal bacterial overgrowth, SIBO, reverse. These efforts thereby restore your ability to ingest prebiotic fibers without diarrhea, bloating, gas, abdominal discomfort, joint pain, and dark emotional feelings. Many people thereby are relieved of irritable bowel syndrome symptoms, fibromyalgia, or restless leg syndrome, or have greater power in reversing autoimmune conditions such as rheumatoid arthritis. Unfortunately, not everybody enjoys reversal of SIBO with our b...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: SIBO grain-free probiotic undoctored wheat belly Source Type: blogs
Hui Tang1, Tao Zeng1* and Luonan Chen1,2,3,4* 1Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China 2CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China 3School of Life Science and Technology, ShanghaiTech University, Shanghai, China 4Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai, China Quantifying or labeling th...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
ConclusionsA protective diverting stoma and laparoscopic surgery significantly decrease the risk of anastomotic leakage. Our nomogram was a useful tool for precise prediction of anastomotic leakage after anterior resection for rectal cancer.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
CONCLUSIONS: The data of this study support the indication for routine MOR for patients diagnosed with locally advanced colorectal cancer with the condition that R0 resection margins are achieved. All mentioned above underline the importance of the experience that the surgical team has in this type of surgeries, in order to achieve optimum results. This experience must concern the preoperative management, surgical technique and postoperative care. KEY WORDS: Colo-rectal cancer, Multi-organ resections, Risk factors. PMID: 30588919 [PubMed - in process]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Conclusion: The need for public awareness about diabetes as an important risk factor of CRC is necessary. Public seminars, school visits and social media will have important role in educating the public with regards to symptoms and diagnostic procedures of CRC. PMID: 30255699 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
CONCLUSIONS: The physical activity, anthropometry, and smoking relationships with colorectal cancer risk differed by subsite, supporting the hypothesis that tumors in different anatomical regions may have distinct etiologies. PMID: 30056182 [PubMed - as supplied by publisher]
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Clin Gastroenterol Hepatol Source Type: research
ConclusionIn this study, T2DM patients were shown to have higher crude IRs of liver, pancreatic and colon cancer, but not of gastric, biliary, and rectal cancer. Moreover, the lower observed IRs of oesophageal cancer in diabetic patients warrants further investigation.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
ConclusionRenal function impairment is an important event that the surgeon has to take into consideration when deciding upon opting for a loop ileostomy to temporarily defunction a colorectal anastomosis.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Abstract Although the overall rate of colorectal cancer (CRC) has remained stable, studies have shown an increase in the rate of CRC in young patients (
Source: The American Surgeon - Category: Surgery Authors: Tags: Am Surg Source Type: research
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