Polyprenylated benzophenone derivatives with a novel tetracyclo[8.3.1.03,11.05,10]tetradecane core skeleton from Clusia burle-marxii exhibited cytotoxicity against GL-15 glioblastoma-derived human cell line.

Polyprenylated benzophenone derivatives with a novel tetracyclo[8.3.1.03,11.05,10]tetradecane core skeleton from Clusia burle-marxii exhibited cytotoxicity against GL-15 glioblastoma-derived human cell line.
Fitoterapia. 2019 Aug 26;:104346
Authors: Ferraz CG, Ribeiro PR, Marques ÉJ, Mendonça R, Guedes MLS, Silveira ER, El-Bachá R, Cruz FG
Abstract
Three new polyprenylated benzophenone derivatives (1-3) were identified in the hexane extract of Clusia burle-marxii trunks, through the isolation and structural elucidation of their methyl derivatives, along with two known polyprenylated benzophenone derivatives sampsonine N (4) and obdeltifolione C (5). Burlemarxiones A (1) and B (2) show an unprecedent tetracyclo[8.3.1.03,11.05,10]tetradecane core skeleton. These compounds are a pair of β-diketones in tautomeric equilibrium, whereas isonemorosonol (3) is the respective β-diketone pair in tautomeric equilibrium with nemorosonol. Burlemarxione A methyl derivative (1a) and sampsonine N exhibited strong in vitro cytotoxic activity against GL-15 glioblastoma-derived human cell line.
PMID: 31465815 [PubMed - as supplied by publisher]

Source: Fitoterapia - August 25, 2019 Category: Biochemistry Authors: Ferraz CG, Ribeiro PR, Marques ÉJ, Mendonça R, Guedes MLS, Silveira ER, El-Bachá R, Cruz FG Tags: Fitoterapia Source Type: research