Obesity as a moderator of the relationship between neighborhood environment and objective measures of physical activity in chilean adults

ConclusionsThere was no significant association between perceived neighborhood environment and PA in people with obesity.ResumenIntroducciónEl objetivo de este estudio fue analizar la asociación entre la percepción del entorno de residencia y medidas objetivas de actividad física (AF) de acuerdo al estado nutricional en población adulta.MétodosEstudio de corte transversal realizado en 161 participantes representativos del estudio CESCAS de Temuco-Chile. La percepción del entorno de residencia fue determinada usando el Modulo Ambiental del IPAQ. La actividad física fue medida objetivamente por un acelerómetro triaxial por siete días consecutivos. El peso y la talla fueron medidos de forma estandarizada. La relación entre en entorno de residencia y los niveles de AF fue analizada mediante modelos de regresion lineal estratificados por estado nutricional.ResultadosLa percepción de los atributos del entorno de residencia que promueven el transporte activo, fue positivamente asociado con el total de AF moderada y vigorosa (β 397 min/week, CI 80–714, p = 0.019) en personas con estado nutricional normal, pero no en personas con sobrepeso u obesidad. Además, vivir cerca de una parada de transporte público fue asociado con altos niveles de AF moderada sólo en personas con estado nutricional normal (β 383 min/week, CI 72–694, p = 0.021). Finalmente,...
Source: Journal of Transport and Health - Category: Occupational Health Source Type: research

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Source: Experimental Aging Research - Category: Geriatrics Authors: Source Type: research
Publication date: Available online 25 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Rui Liu, Meina Wang, Enjie Li, Yang Yang, Jiaxin Li, Siyu Chen, Wen-Jun Shen, Salman Azhar, Zhigang Guo, Zhigang HuAbstractObesity is associated with an increased risk of developing insulin resistance (IR) and type 2 diabetes (T2D). A diverse group of factors including miRNA has been implicated in the pathogenesis of these two metabolic conditions, although underlying molecular mechanisms involved are not well defined. Here, we provide evidence that hepatic miR-125a levels are dimin...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
Publication date: Available online 24 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Lu Han, Stefanie Bittner, Dachuan Dong, Yuan Cortez, Alex Bittner, Jackie Chan, Meenakshi Umar, Wen-Jun Shen, Richard G. Peterson, Fredric B. Kraemer, Salman AzharAbstractIn recent years, the prevalence of obesity, metabolic syndrome and type 2 diabetes is increasing dramatically. They share pathophysiological mechanisms and often lead to cardiovascular diseases. The ZDSD rat was suggested as a new animal model to study diabetes and the metabolic syndrome. In the current study, we have furthe...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 25 January 2020Source: Life Sciences in Space ResearchAuthor(s): Deivydas Kiznys, Jone Vencloviene, Irena MilvidaitėAbstractIt is shown the statistical associations between space weather pattern and humans’ cardiovascular system. We investigated the association between space weather events and cardiovascular characteristics of 4076 randomly selected patients with acute coronary syndrome (ACS) who were admitted for inpatient treatment in Kaunas city, Lithuania during 2000–2005. We hypothesized that days of the space weather events, 1–3 days after, and the period between ...
Source: Life Sciences in Space Research - Category: Biology Source Type: research
ConclusionsThere were rapid changes within 4 weeks after RYGB: signs of enhanced parasympathetic nerve activity, reduced morning cortisol, and enhanced incretin and glucagon responses to glucose. The findings suggest that neurohormonal mechanisms can contribute to the rapid improvement of insulin resistance and glycemia following RYGB in type 2 diabetes.
Source: Endocrine - Category: Endocrinology Source Type: research
Publication date: Available online 25 January 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Jiadela Teliewubai, Ximin Fan, Hongwei Ji, Rusitanmujiang Maimaitiaili, Jiamin Tang, Song Zhao, Shikai Yu, Chen Chi, Yawei Xu, Yi ZhangAbstractBackground and AimsMetabolic unhealthiness and obesity are both associated with an increased risk of cardiovascular disease. We aimed to investigate the significance of metabolic unhealthiness and obesity in organ damages in a community-based elderly cohort.Methods and results3325 elderly participants (>65 years old) were recruited in northern Shanghai. Associatio...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
ConclusionsThere was an improvement in informing patients of overweight/obesity status. However, less than a quarter of young adults with overweight were notified in recent surveys, compromising the opportunities of preventing overweight from becoming obesity in early adulthood.Graphical abstract
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
rio S Abstract CONTEXT: The time-to-glucose-peak following the oral glucose tolerance test (OGTT) is a highly reproducible marker for diabetes risk. In obese youths, we lack evidence for the mechanisms underlying the effects of the TCF7L2 rs7903146 variant on glucose peak. METHODS: We analyzed the metabolic phenotype and the genotype for the TCF7L2 rs7903146 in 630 obese youths with normal (NGT) and impaired (IGT) glucose tolerance. Participants underwent a 3-hour, 9-point OGTT to estimate, using the oral minimal model, the disposition index (DI), the static (φstatic) and dynamic (φdynamic) components...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
CONCLUSION: In this study, we demonstrated that silibinin as an anti-inflammatory therapy is a potential alternative to manage obesity, as well as its related complications. Moreover, silibinin-based therapies could further evolve as a novel treatment to manage various inflammation-driven disorders. PMID: 31973745 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Publication date: Available online 24 January 2020Source: Molecular and Cellular EndocrinologyAuthor(s): Cara E. Porsche, Jen B. Delproposto, Elise Patrick, Brian F. Zamarron, Carey N. LumengAbstractAdipose tissue derived chronic inflammation is a critical component of obesity induced type II diabetes. Major histocompatibility complex II (MHCII) mediated T cell activation within adipose tissue is one mechanism that contributes to this phenotype. However, the contribution of dendritic cells as professional antigen presenting cells in adipose issue has not previously been explored. Using ItgaxCre x MHCIIfl/fl (M11cKO) mice w...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
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