Tonsillar and Adenoid Noncaseating, Epithelioid Granulomas in a Young Girl
Waldeyer's lymphatic ring granulomas in children are infrequent, and may represent an underlying systemic disease, often nondiagnosed before adenotonsillectomy is performed. The authors report on a 5-year-old otherwise healthy girl presented with remarkable tonsillar asymmetry as well as adenoid hypertrophy, with no systemic signs or complaints. Adenotonsillectomy was performed to rule out malignancy. Blood workup was normal. Microscopy of both adenoidectomy and tonsillectomy specimens showed multiple foci of epithelioid, noncaseating granulomas with giant multinucleated cells surrounded by nonspecific chronic inflammation. Immunostainings for B-cell markers, Ki-67, and Ziehl-Neelson were negative. This unusual pathology raised a differential diagnosis which included inflammatory diseases (sarcoidosis, Crohn's disease), foreign body reaction, lymphoma and infections (tuberculosis, fungi). However, none of these entities could be attributed to the girl's condition, and the reason for her pathologic findings remained unknown.
[Daily Trust] The Federal Government has pledged $12 million to the Global Fund to tackle HIV, tuberculosis and malaria.
Publication date: Available online 20 October 2019Source: Microchemical JournalAuthor(s): Archana Kushwaha, Neha Gupta, Juhi Srivastava, Ambareesh Kumar Singh, Meenakshi SinghAbstractHere, a selective sensing technology for the drug ethionamide used to treat multi-drug resistant tuberculosis is developed based on molecular imprinting. The molecular imprinting matrix is developed strategically by molecular modelling via density functional theory. 3-Thiophene acetic acid was predicted as suitable functional monomer for imprinting ethionamide. Polymeric film was formed on the surface of glassy carbon electrode by electropolym...
Ustekinumab was more effective than placebo for inducing and maintaining remission and promoting mucosal healing in a study of adults with moderately to severely active ulcerative colitis.FDA Approvals
Publication date: Available online 20 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): R. Sacco, S. Shah, R. Leeson, V. Moraschini, C.F. de Almeida Barros Mourão, O. Akintola, A. LalliAbstractTumour necrosis factor-α (TNF-α) inhibitors are increasingly being used as immunomodulators to manage inflammatory conditions such as rheumatoid arthritis and Crohn’s disease. Reported serious side effects include an increased incidence of lymphoma and greater susceptibility to infections such as tuberculosis. The aim of this systematic review was to find out whether there is an ...
HORSHAM, PENNSYLVANIA, October 21, 2019– The Janssen Pharmaceutical Companies of Johnson&Johnson announced today the U.S. Food and Drug Administration’s (FDA) approval of Stelara (ustekinumab) for the treatment of adult patients...
ConclusionsThe present study has verified the ethnomedical use of C. mas for the treatment of ulcerative colitis.Graphical abstract
DiscussionGiven the multiorgan system potential adverse side effects of prednisone, proving noninferiority of an alternate regimen would be sufficient to make the alternative compare favorably to standard dose steroids. This is the first ever clinical trial in cardiac sarcoidosis and thus in addition to the listed goals of the trial, we will also establish a multi-center, multinational cardiac sarcoidosis clinical trials network. Such a collaborative infrastructure will enable a new era of high quality data to guide physicians when treating cardiac sarcoidosis patients.
ConclusionsShort-term exercises do not appear to convey benefits to quality of life and other psychosocial outcomes. Subgroup analysis showed that physical activity together with mental exercise may be more beneficial to lymphoma patients, but it needs more research to verify this finding. The interpretation of this result should be cautious due to the baseline difference, completion efficiency of intervention process, and high heterogeneity.
Conditions: Vitamin D Deficiency; Crohn Disease Interventions: Drug: Vitamin D; Drug: Placebo oral capsule Sponsors: Nanjing University School of Medicine; Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Not yet recruiting
Condition: Ulcerative Colitis Intervention: Drug: Mesalazine Sponsor: Copenhagen University Hospital, Hvidovre Not yet recruiting