Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43 G298S ALS mouse model
ConclusionDTI mapping ofTDP-43G298S mice demonstrated progression in motor areas M1/M2. WBSS and TFAS are useful techniques to localizeTDP-43G298S associated alterations over time in this ALS mouse model, as a biological marker.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research