Feed-forward Loop between Body Composition, Strength and Performance in Older Adults

We present evidence of a feed-forward loop relationship between certain components of the frailty syndrome: body composition, strength and physical performance level.The evidence has been found by performing statistical analysis on measures from 878 females and 588 males aged 60-97, participating in the Rancho Bernardo Study, followed for at least three visits over 12 years. In the analysis, we have used fat mass and lean mass (measured by whole body DXA scans), grip strength (measured by dynamometer) and time to get up and walk a certain distance. The results provide evidence of a feed-forward loop between these variables. The results also suggest that adverse changes in body composition would not only reduce the physical performance and grip strength, but the changes would further result in adverse changes in body composition. Our findings support the hypothesis that feed-forward loops are present between the components of the frailty syndrome at the time of development of frailty, which itself may be a manifestation of dysregulated energetics.
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research

Related Links:

Despite its frequency in Mexico, research on migrant kidnapping is scant. We estimate that up to 250,000 migrants may have been kidnapped between 2006 and 2018. Even less is known about women as perpetrators in kidnapping operations. Moreover, in Mexico, r...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news
ConclusionCombined laparoscopic pouch resizing and distalization are safe and can lead to adequate weight loss. This technique allows the combination of an added restriction and malabsorption to the previous RYGB and could lead to an improved weight loss.
Source: Obesity Surgery - Category: Surgery Source Type: research
CONCLUSIONS: In this first study to address optimisation of CBCT imaging of root canal anatomy, a similar threshold dose for both scanners was identified for M1Ms with simple-moderate MB2 canal complexity. Increasing dose to enhance visualisation of more complex canal anatomy was ineffective. Selection of standard protocols (while avoiding lower kV/mA protocols) instead of high-resolution scans was a practical means of reducing patient dose. CNR is not a transferable measure of image quality. PMID: 32464075 [PubMed - as supplied by publisher]
Source: Dentomaxillofacial Radiology - Category: Radiology Tags: Dentomaxillofac Radiol Source Type: research
ConclusionsPatients who receive neoadjuvant chemotherapy for liver metastasis surgery have a greater splenic volume increase, which correlates with NAFLD and a lower survival.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Authors: Montrucchio G, Sales G, Scanu M, Bosso S, Brazzi L PMID: 32463213 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
AbstractPurpose of ReviewGoal of this review article was to summarize and evaluate the current developments in nuclear medicine cardiovascular imaging with focus on PET/MR imaging. Furthermore, it should highlight recent topics of interest, such as sarcoidosis, inflammation, and cardiac amyloidosis for instance, which have not properly characterized with PET/MRI yet.Recent FindingsIn the last years there have been advances in experimental tracers and clinical research especially for inflammatory cardiac diseases. Most articles still focus PET/CT rather than PET/MRI, which is mostly due to a limited number of PET/MRI center...
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research
CONCLUSION: Each drug when used as monotherapy against Leishmania spp. was effective, but the combination therapy was more effective than the individual drugs due to the additive or synergistic effects. PMID: 32463611 [PubMed - as supplied by publisher]
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
Publication date: Available online 28 May 2020Source: Radiation Physics and ChemistryAuthor(s): Chen Ew-Jun, Tan Teik Hin, Chew Ming Tsuey
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
CONCLUSIONS: These correlates should be confirmed in other studies and, if supported, should be considered in the promotion and design of urban trails. PMID: 32464596 [PubMed - as supplied by publisher]
Source: Journal of Physical Activity and Health - Category: Sports Medicine Tags: J Phys Act Health Source Type: research
Publication date: 15 October 2020Source: Journal of Molecular Structure, Volume 1218Author(s): K. Aswaniya, M.B. Jessie Raj, S. Gowri, G. Vinitha
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
More News: Geriatrics | PET Scan | Statistics | Study