Anesthetic Management of Patients with Hereditary Muscular Dystrophin Disorders

Muscular dystrophy (MD) refers to a group of hereditary diseases characterized by painless degeneration and loss-of-function of skeletal muscles. Out of these, the X-linked recessive types such as Duchenne (DMD) and Becker muscular dystrophies (BMD) remain the most common subtypes. Both DMD and BMD result from a deficiency of the muscle-stabilizing protein dystrophin, whose expression is either completely lost (as in DMD) or dysfunctional (as in BMD). This, in turn, results in weakness and motor delay that eventually proves to be fatal from respiratory failure.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research