Unexpected excessive apixaban exposure: case report of a patient with polymorphisms of multiple apixaban elimination pathways

Apixaban effectively lowers the risk of ischemic stroke and systemic embolism in patients with non-valvular atrial fibrillation. Systemic exposure to a given apixaban dose depends on multiple clearance pathway...

Source: BMC Clinical Pharmacology - August 29, 2019 Category: Drugs & Pharmacology Authors: Andrea Huppertz, Caspar Grond-Ginsbach, Chris Dumschat, Kathrin I. Foerster, J ürgen Burhenne, Johanna Weiss, David Czock, Jan C. Purrucker, Timolaos Rizos and Walter E. Haefeli Tags: Case report Source Type: research