Phase I trials as therapeutic options: (usually) a betrayal of evidence-based medicine

Nature Reviews Clinical Oncology, Published online: 30 August 2019; doi:10.1038/s41571-019-0264-7Many argue that phase I cancer trials are a therapeutic option for eligible patients. I question this position and offer a more nuanced view that differentiates between types of trials. Patients seeking treatment might legitimately pursue phase I trials, although labelling all phase I trials as therapeutic contradicts the spirit of evidence-based medicine.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research