A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials.

This study aims to bridge preclinical and clinical data with the identification of a gene signature in B cells that is associated with protection from SIV and HIV infection by providing a new approach for evaluating future vaccine candidates.
PMID: 31462510 [PubMed - in process]

Source: Topics in HIV Medicine - August 27, 2019 Category: Infectious Diseases Authors: Ehrenberg PK, Shangguan S, Issac B, Alter G, Geretz A, Izumi T, Bryant C, Eller MA, Wegmann F, Apps R, Creegan M, Bolton DL, Sekaly RP, Robb ML, Gramzinski RA, Pau MG, Schuitemaker H, Barouch DH, Michael NL, Thomas R Tags: Sci Transl Med Source Type: research