Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC).

CONCLUSION: The prognostic significance of CHL1 makes it a potential prognostic and therapeutic target and underlines its role as a tumour suppressor. Further validation studies and functional analyses are needed to investigate its potential role in tumourigenesis and dissemination.
PMID: 31372722 [PubMed - indexed for MEDLINE]

Source: Clinical Lung Cancer - August 30, 2019 Category: Cancer & Oncology Authors: Hötzel J, Melling N, Müller J, Polonski A, Wolters-Eisfeld G, Izbicki JR, Karstens KF, Tachezy M Tags: J Cancer Res Clin Oncol Source Type: research