Updated Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents Released

The National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the HIV Medicine Association (HIVMA) of the Infectious Diseases Society of America (IDSA) announce the release of the updated Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents.   Selected key updates to the guidelines include the following: New information on the diagnosis and management of immune reconstitution inflammatory syndrome (IRIS), particularly as it relates to tuberculosis and cryptococcosis. New guidance for managing IRIS related to each opportunistic infection (OI) is provided. Updated information on the management of hepatitis B and hepatitis C. Immunization strategies for preventing pneumococcal disease and human papillomavirus (HPV) have been updated to reflect the availability of new vaccines and new data. Drug interaction information has been updated, particularly as it relates to antiretroviral medications that have been approved since the last update of the guidelines in 2009. In addition to information on the clinical manifestations, diagnosis, and prevention and treatment of each OI, the guidelines include tables at the end of each chapter and summary tables at the end of the document that list therapeutic options for preventing and treating OIs, adverse drug reactions, pharmacokinetic interactions, dosing recommendations in patients with renal insufficiencies, and therapeutic con...

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Publication date: Available online 31 March 2020Source: Preventive Veterinary MedicineAuthor(s): Tiny Motlatso Hlokwe, Marcia Mogano Ratanna
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
CONCLUSION: These results suggested that rHP-NAP possesses the potential for use as an adjuvant of dendritic cell-based vaccine in anti-melanoma treatment. PMID: 32224538 [PubMed - in process]
Source: Iranian Journal of Immunology - Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research
CONCLUSION: Evaluation of immune status based on PD-L1 pleural concentration and Th2 to Th1 ratio might predict the risk of MDR-TB occurrence. PMID: 32224537 [PubMed - in process]
Source: Iranian Journal of Immunology - Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research
Please don't get me wrong. I've seen other people try to put our present crisis in context, or discuss the costs vs. the benefits of certain actions, and be widely condemned for insensitivity or even sociopathy. I remember after the 9/11 attack, when people who tried to explain the motivations or sociological origins of Al Qaeda and similar movements faced the same sort of criticism. You weren't allowed to think about the problem, people weren't ready for any sort of moral confusion. In what I am about to say, I am not arguing against saving lives, on the contrary. I'm just trying to explain something about where we are in...
Source: Stayin' Alive - Category: American Health Source Type: blogs
Purpose of review The universal adoption of electronic health records, improvement in technology, and the availability of continuous monitoring has generated large quantities of healthcare data. Machine learning is increasingly adopted by nephrology researchers to analyze this data in order to improve the care of their patients. Recent findings In this review, we provide a broad overview of the different types of machine learning algorithms currently available and how researchers have applied these methods in nephrology research. Current applications have included prediction of acute kidney injury and chronic kidney d...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: EPIDEMIOLOGY AND PREVENTION: Edited by Navdeep Tangri Source Type: research
Purpose of review The sensitivity of semen analysis for detection of infertility remains low. Many factors not measured in traditional semen analysis may contribute to male factor infertility. DNA fragmentation, oxidative stress, and sperm aneuploidy are three factors that may contribute further information to the evaluation when semen analysis is inconclusive. Recent findings DNA fragmentation measures the destruction of and failure to repair damage to DNA. Increased DNA fragmentation has been used as a marker for oxidative stress as well as toxic exposure. The oxidative stress adduct measures DNA aberrations, which ...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: GENDER MEDICINE, INFERTILITY AND ERECTILE FUNCTION: Edited by Ryan Flannigan and Ranjith Ramasamy Source Type: research
Purpose of review This review provides an overview of currently ongoing clinical trials evaluating the combination of immune checkpoint inhibitors (CPI) with other therapies in locally advanced or metastatic urothelial cancer and the rationale for this combination approach. We discuss the preliminary results from early data presented at recent meetings regarding the efficacy and safety of novel combination therapies including a CPI for metastatic urothelial cancer. Recent findings CPI emerged as novel first-line or second-line treatment options in advanced and metastatic urothelial cancer (mUC). Although the response ...
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: BLADDER CANCER: Edited by Juan Palou and Óscar Rodríguez Faba Source Type: research
BACKGROUND: Victimisation of women is encountered in all countries across the world, it damages the mental and physical health of women. During pregnancy and the postpartum period, women are at a greater risk of experiencing violence from an intimate partn...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Firearm violence may indirectly affect health among pregnant women living in neighborhoods where it is endemic. We used birth, death, emergency department, and hospitalization data from California from 2007-2011 to estimate the association between living i...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
By Ehtesham ShahidDUBAI, Apr 1 2020 (IPS-Partners) Global crises need global solutions yet some adjustments will have to be made if the world has to adopt a multilateral approach toward tackling the Corona pandemic, a senior academic said on Tuesday, March 31. Participating in an e-symposium organized by the think-tank, TRENDS Research &Advisory, Prof. Yong Wang of the School of International Studies and Director, Center for International Political Economy at Peking University, said the G-20 has already taken an initiative and more such efforts are needed. “We have our national interests but for facing challenge...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Conferences Health Source Type: news
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