Detection of norovirus in air samples in a non-vomiting patient: implications of testing saliva for norovirus in an immunocompromised host

Publication date: Available online 25 July 2019Source: Journal of Hospital InfectionAuthor(s): V.C.C. Cheng, S-C. Wong, K.H.Y. Chiu, C.C.Y. Yip, S.C.Y. Wong, K-Y. Yuen
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research

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A matron at Swansea Bay University Health Board said people can catch norovirus from surfaces in busy areas like supermarkets and should wash their hands with soap and water to avoid it.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
zevic Human noroviruses (NoVs) are a genetically diverse, constantly evolving group of viruses. Here, we studied the effect of NoV pre-existing immunity on the success of NoV vaccinations with genetically close and distant genotypes. A sequential immunization as an alternative approach to multivalent NoV virus-like particles (VLPs) vaccine was investigated. Mice were immunized with NoV GI.3, GII.4-1999, GII.17, and GII.4 Sydney as monovalent VLPs or as a single tetravalent mixture combined with rotavirus VP6-protein. Sequentially immunized mice were primed with a trivalent vaccine candidate (GI.3 + GII.4-1999 + VP6) an...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Publication date: Available online 31 October 2019Source: Meta GeneAuthor(s): Yoshiyuki Suzuki, Maho Nishimura, Tatsuya Inoue, Yuki KobayashiAbstractDue to the progress in the sequencing technology, the number of nucleotide sequences for pathogens deposited in the public databases has been increasing rapidly. Consequently, in the molecular evolutionary analyses of pathogens, it may occasionally be difficult to include all the available sequences and necessary to reduce the number of sequences to accomplish computation within a realistic time frame. Here several methods for reducing the number of sequences were evaluated us...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Abstract In Japan, from 2000 to 2018, for Vibrio parahaemolyticus and Salmonella food poisonings, the annual number of the outbreaks and that of the patients decreased exponentially though the size of the individual outbreaks (the number of patients per outbreak) tended to become larger. For food poisonings caused by Campylobacter, the annual number of the outbreaks increased exponentially while the outbreak size became smaller and the annual number of the patients remained almost unchanged. For food poisoning caused by norovirus, both the number of the outbreaks and that of the patients remained high throughout. ...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research
ConclusionsResidual antinoroviral hand sanitizers may reduce infection risks for up to 4 hours.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
ena Gutiérrez-Escolano It is known that levels of the anti-apoptotic protein survivin are reduced during Murine norovirus MNV-1 and Feline calicivirus (FCV) infection as part of the apoptosis establishment required for virus release and propagation in the host. Recently, our group has reported that overexpression of survivin causes a reduction of FCV protein synthesis and viral progeny production, suggesting that survivin may affect early steps of the replicative cycle. Using immunofluorescence assays, we observed that overexpression of survivin, resulted in the reduction of FCV infection not only in transfected...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
AbstractNorovirus is commonly associated with food and waterborne outbreaks. Genetic susceptibility to norovirus is largely dependent on presence of histo-blood group antigens (HBGA), specifically ABO, secretor, and Lewis phenotypes. The aim of the study was to determine the association between HBGAs to norovirus susceptibility during a large norovirus foodborne outbreak linked to genotype GII.6 in an office-based company in Stockholm, Sweden, 2015. A two-episode outbreak with symptoms of diarrhea and vomiting occurred in 2015. An online questionnaire was sent to all 1109 employees that had worked during the first outbreak...
Source: Food and Environmental Virology - Category: Virology Source Type: research
NOROVIRUS, also known as the winter vomiting bug, is causing havoc across many parts of the UK with outbreaks leading to school and hospital ward closures. Which parts of the UK have been hit, how can you spot symptoms and what ’s the best form of treatment?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
NOROVIRUS warnings have been issued after suspected outbreaks at a school and hospitals. What are the symptoms of the illness, how long does it last, and how can it be treated?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Abstract Bile acids have been reported as important co-factors promoting human and murine Norovirus (NoV) infections in cell culture. The underlying mechanisms are not resolved. Using chemical shift perturbation (CSP) NMR experiments we have identified a low-affinity bile acid binding site of a human GII.4 NoV strain. Long-timescale MD simulations reveal the formation of a ligand-accessible binding pocket of flexible shape, allowing the formation of stable viral coat protein:bile acid complexes in agreement with experimental CSP data. CSP NMR experiments also show that this mode of bile acid binding has minor infl...
Source: Chembiochem - Category: Biochemistry Authors: Tags: Chembiochem Source Type: research
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