Stimulation-induced side effects after Deep Brain Stimulation - a systematic review.

CONCLUSION: DBS of subthalamic nucleus should be seen as the most hazardous place of implantation. As a result there is a strong need of "gold standards" based on the connectivity research and closer cooperation of scientists and clinicians. PMID: 31452489 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

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In this study, platinum electrodes were fabricated on the bio-based poly(ethylene terephthalate) (Bio-PET) substrates for the development of flexible electrochemical sensors for the detection of Parkinson's disease biomarkers. Dopamine was detected by voltammetric measurements, displaying a 3.5 × 10−5 mol L−1 to 8.0 × 10−4 mol L−1 linear range with a limit of detection of 5.1 × 10−6 mol L−1. Parkinson's disease protein 7 (PARK7/DJ-1) was successfully detected by electrochemical impedance spectroscopy after elec...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
BACKGROUND: Suicide is the third leading cause of death worldwide among youth aged 10- to 19, and mental disorders are often associated in the etiology of suicidal behavior. Mental disorders are often under-diagnosed and under-treated in young people, a si...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Suicide prevention remains challenging among youth, as many do not disclose suicidal ideation. Nearly one-third of American Indian and Alaska Native (AI and AN, tribal, or native) youth see concerning messages on social media at least weekly. ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Young Adults Source Type: news
This article discusses the development and initial validation of the Dual Self-Directed Humor Scale (DSDHS), the first instrument to evaluate individual differences in the two dimensions of self-directed humor (SDH). The DSDHS assumes two distinct dimensions: Deleterious SDH and Benign SDH. While the former is potentially harmful to well-being, the latter is potentially beneficial. By employing 400 participants in Study 1, the validity of the two-factor model of the DSDHS was demonstrated. In Study 2, which included 446 participants, evidence for concurrent validity was shown by correlating the DSDHS with other humor measu...
Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
Publication date: 15 April 2020Source: Personality and Individual Differences, Volume 157Author(s): Martin M. Smith, Simon B. Sherry, Paul L. Hewitt, Gordon L. Flett, Peter A. Hall, Dayna L. Lee-BaggleyAbstractThe existential model of perfectionism and depressive symptoms (EMPDS) posits difficulties accepting the past (i.e., viewing past experiences as incoherent, dissatisfying, and meaningless) explains when and why socially prescribed perfectionism (i.e., perceiving others as requiring perfection of the self) confers risk for depressive symptoms. However, excessive use of cross-sectional designs, an over-reliance on unde...
Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
Publication date: March 2020Source: Epilepsy &Behavior, Volume 104, Part AAuthor(s): Jeffrey Do, Richard J. Webster, Patricia E. Longmuir, Sara Ieradi, Deepti Reddy, Sharon Whiting, Daniela PohlAbstractObjectiveThe aim of this study was to longitudinally characterize in children with epilepsy the objective and subjective sleep quality and the relationship between increased physical activity and sleep as well as measures of psychosocial well-being.MethodsBaseline physical activity and sleep were established in children with epilepsy over four weeks, prior to a 12-week exercise intervention (weekly meeting with exercise ...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This study aimed to explore the quality of life (QoL) of adult patients with epilepsy (PwE) in Australia and its relationship with comorbidities and adverse events (AEs) from antiepileptic drugs (AEDs).MethodsCross-sectional surveys were completed by PwE, or carer proxies, recruited via the online pharmacy application MedAdvisor and Australian PwE Facebook groups from May to August 2018. Data were collected on demographics, epilepsy severity and management, AEs, comorbidities, and QoL (using the Patient-Weighted Quality of Life in Epilepsy Inventory [QOLIE-10-P] total score). Two linear regression models were constructed t...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 20 January 2020Source: Computers in Human BehaviorAuthor(s): Jan Dieris-Hirche, Magdalena Pape, Bert Theodor te Wildt, Aram Kehyayan, Maren Esch, Salam Aicha, Stephan Herpertz, Laura BottelAbstractCurrent psychological models for the development of specific internet-use disorders consider predisposing core characteristics (e.g. biopsychological constitution, psychopathology, early childhood experiences, and personality traits) that are involved in the early behavioral addiction process. The cross-sectional study discussed in this paper examined several likely relevant psychological variab...
Source: Computers in Human Behavior - Category: Information Technology Source Type: research
Authors: Quarracino C, Otero-Losada M, Capani F, Pérez-Lloret S Abstract Introduction: Autonomic dysfunction is one of the most frequent and disabling non-motor symptoms of Parkinson's disease (PD). It includes, among others, orthostatic hypotension (OH), sialorrhea, constipation, erectile dysfunction (ED), urinary dysfunction, and diaphoresis. They are usually under-recognized and suboptimally managed.Areas covered: Recommended treatments for dysautonomias are summarized with a description of the mechanism of action and observed results. The pathophysiology of each disorder is reviewed to pinpoint possible ...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Authors: Ali Z, Tegin C, El-Mallakh RS Abstract Introduction: Lurasidone has been approved in the United States as a monotherapy and adjunct for acute bipolar I depression, as well as an antipsychotic for patients with schizophrenia.Areas covered: Herein, the authors review the pharmacodynamics and pharmacokinetics of lurasidone as well and the major randomized clinical trials. The authors also provide their expert opinion.Expert opinion: Lurasidone has not been studied in patients with mania or bipolar psychosis. It has been studied, both as a monotherapy and adjunctive treatment to lithium or valproate, in acute ...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
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