Properly prescribed, proton pump inhibitors are largely safe, but precautions are needed to prevent potential problems, overuse and misuse

AbstractAdverse events have been widely reported in users of popular proton pump inhibitors (PPIs). Most data come from observational studies, with clear causation rarely demonstrated. Evidence linking PPIs to gastrointestinal infections is stronger and some drug interactions are important. The use of PPI is often prolonged, without a clear reason for continued therapy. PPIs should be prescribed after a careful assessment of risks and benefits and their use reviewed regularly.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research