Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

In this study, Zhang et  al. restore B cell immunity in the elderly with spermidine, a cellular polyamine metabolite depleted with age. They find that autophagy is maintained by spermidine via promoting eIF5A function and TFEB translation. This pathway provides an explanation for the age-related decline of autophagy.

Source: Molecular Cell - August 28, 2019 Category: Cytology Authors: Hanlin Zhang, Ghada Alsaleh, Jack Feltham, Yizhe Sun, Gennaro Napolitano, Thomas Riffelmacher, Philip Charles, Lisa Frau, Philip Hublitz, Zhanru Yu, Shabaz Mohammed, Andrea Ballabio, Stefan Balabanov, Jane Mellor, Anna Katharina Simon Tags: Article Source Type: research