Axially chiral N,N'-dioxides ethers for catalysis in enantioselective allylation of aldehydes.

Axially chiral N,N'-dioxides ethers for catalysis in enantioselective allylation of aldehydes. Chirality. 2019 Aug 28;: Authors: Wu S, Xing Y, Wang J, Guo X, Zhu H, Li W Abstract A series of axially chiral ethers synthesized from biscarboline N,N'-dioxides, (S)-1a to (S)-1n, was investigated in enantioselectivity addition reactions of allyltrichlorosilane with a series of substituted aldehydes, including bulky substituted aldehydes. High enantioselectivities (up to 96%ee) were achieved using the catalyst (S)-1k at 1 mol % loading. PMID: 31456306 [PubMed - as supplied by publisher]
Source: Chirality - Category: Molecular Biology Authors: Tags: Chirality Source Type: research