Decreased pulmonary vascular distensibility in adolescents conceived by in vitro fertilization

AbstractSTUDY QUESTIONWhat is the functional relevance of decreased pulmonary vascular distensibility in adolescents conceived by IVF?SUMMARY ANSWERChildren born by IVF have a slight decrease in pulmonary vascular distensibility observed during normoxic exercise that is not associated with altered right ventricular function and aerobic exercise capacity.WHAT IS KNOWN ALREADYGeneral vascular dysfunction and increased hypoxic pulmonary hypertension have been reported in ART children as compared to controls. Pulmonary hypertension or decreased pulmonary vascular distensibility may affect right ventricular function and thereby possibly limit maximal cardiac output and aerobic exercise capacity.STUDY DESIGN, SIZE, DURATIONThis prospective case-control study enrolled 15 apparently healthy adolescents conceived by IVF/ICSI after fresh embryo transfer paired in a 2 to 1 ratio to 30 naturally conceived adolescents between March 2015 and May 2018.PARTICIPANTS/MATERIALS, SETTING, METHODSFifteen IVF/ICSI adolescents and 30 controls from singleton gestations matched by age, gender, weight, height and physical activity underwent exercise echocardiography, lung diffusion capacity measurements and a cycloergometer cardiopulmonary exercise test. A pulmonary vascular distensibility coefficient α was determined from the pulmonary arterial pressure (PAP) versus cardiac output (Q) relationships. Pulmonary capillary volume (Vc) was calculated from single breath nitric oxide and carbon monoxide lu...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research