FDA warns pregnant women to not use certain migraine prevention medicines
The U.S. Food and Drug Administration is alerting health care providers and patients that medications including and related to valproate sodium can cause decreased IQ scores in children whose mothers took the medication during pregnancy. Therefore, these drugs are being contraindicated for (should never be used by) pregnant women for the prevention of migraine headaches. Valproate products include valproate sodium (Depacon), divalproex sodium (Depakote, Depakote CP, and Depakote ER), valproic acid (Depakene and Stavzor), and their generics.
This article focuses on potential toxic risk to the fetus of medications deemed necessary to manage several common maternal neurologic issues: m ultiple sclerosis, epilepsy, and headache during pregnancy and postpartum. It is important for the practitioner to have an understanding beyond the category system to understand the potential toxic risks to the infant.
CONCLUSION: Men and women with CVD or those at increased risk of CVD perceived new research on conventional and sex- and gender-related risk factors as a priority. These findings may guide researchers and funders in further prioritising new CVD research. PMID: 33025404 [PubMed - as supplied by publisher]
Discussion Herpes simplex virus (HSV) infections are common with an estimated 50% of the US population being infected by age 30, and with latent infection harboring in the trigeminal nerve in 100% of people by age 60 years. HSV infections can cause a vesicular or pustular skin rash that is painful, burning or pruritic and also flu-like symptoms with fever, chills, headache, and fatigue. HSV can also be asymptomatic. To laymen, herpes simplex viruses cause “cold sores,” but to health care personnel, herpes causes many systemic infections including eczema herpeticum, folliculitis, herpes gladiatorum, whitlow, e...
PMID: 32990322 [PubMed - as supplied by publisher]
Title: 1 Woman in 5 With Migraine Avoiding Pregnancy: StudyCategory: Health NewsCreated: 9/21/2020 12:00:00 AMLast Editorial Review: 9/22/2020 12:00:00 AM
TUESDAY, Sept. 15, 2020 -- Migraine has a considerable impact on women's pregnancy plans, with about 20 percent avoiding pregnancy due to migraine, according to a study published online Sept. 15 in the Mayo Clinic Proceedings. Ryotaro Ishii, M.D.,...
(Elsevier) A survey of 607 women who suffer from severe migraine found twenty percent of the respondents are currently avoiding pregnancy because of their migraines. The women avoiding pregnancy due to severe migraine tend to be in their thirties, are more likely to have migraine triggered by menstruation, and are more likely to have very frequent attacks (chronic migraine) compared to their counterparts who are not avoiding pregnancy, according to a new study in Mayo Clinic Proceedings.
To evaluate the effect of migraine on women ’s pregnancy plans.
Due to the healthcare burden associated with migraines, prompt and effective treatment is vital to improve patient outcomes and ED workflow. This was a prospective, randomized, double-blind trial. Adults who presented to the ED with a diagnosis of migraine from August of 2019 to March of 2020 were included. Pregnant patients, or with renal impairment were excluded. Patients were randomized to receive intravenous magnesium, prochlorperazine, or metoclopramide. The primary outcome was change in pain from baseline on a numeric rating scale (NRS) evaluated at 30 min after initiation of infusion of study drug.
ConclusionHere we demonstrate the first known case of successful elective induction of vaginal delivery and transsphenoidal intervention in a near full term gravid patient presenting with pituitary apoplexy and acute SARS-CoV-2 infection. Further reports may help determine if there is a causal relationship or if these events are unrelated. Close adherence to guidelines for caregivers can greatly reduce risk of infection.