Outcomes of Extended Infusion Cefepime in Pediatric Patients

The objective of this study was to compare clinical outcomes in children receiving extended and traditional infusion cefepime. Methods This was a retrospective cohort study of patients aged 31 days to 17 years receiving extended or traditional infusion cefepime for at least 48 hours for a susceptible gram-negative bacteremia at a tertiary care children's hospital. The primary outcome was a composite clinical outcome comprised of infection-related mortality within 14 days of antibiotic initiation, bacteremic relapse within 30 days of culture clearance, and treatment failure. Results Sixty-seven patients were included; 21 (31.3%) received extended infusion, and 46 (68.7%) received traditional infusion. Extended infusion patients were older and larger than traditional infusion patients with a median (interquartile range) age of 7 (0.8–11.5) years versus 0.5 (0.2–2) years (P = 0.05) and weight of 23.7 (8.2–44.2) kg versus 6.2 (2.4–13.1) kg (P
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Original Articles Source Type: research