Renal oxygenation during the early stages of adenine-induced chronic kidney disease.

Renal oxygenation during the early stages of adenine-induced chronic kidney disease. Am J Physiol Renal Physiol. 2019 Aug 28;: Authors: Ullah MM, Ow CPC, Hilliard Krause LM, Evans RG Abstract To assess whether renal hypoxia is an early event in adenine-induced chronic kidney disease (Ad-CKD), adenine (100 mg) or its vehicle were administered to male Sprague-Dawley rats by daily oral gavage for 7 days. Kidney oxygenation was assessed by (i) blood oximetry and Clark electrode in thiobutabarbital-anesthetized rats, (ii) radiotelemetry in unanesthetized rats, and (iii) through expression of hypoxia inducible factor (HIF-1α and HIF-2α) protein. After 7 days of treatment, under anesthesia renal oxygen delivery was 51% less, while renal oxygen consumption was 65% less, in adenine-treated than vehicle-treated rats. Tissue PO2 measured by Clark electrode was similar in the renal cortex but 44% less in the medulla of adenine-treated rats than vehicle-treated rats. In contrast, in unanesthetized rats, both cortical and medullary tissue PO2 measured by radiotelemetry remained stable across 7 days of adenine treatment. Notably, anesthesia and laparotomy led to greater reductions in medullary tissue PO2 measured by radiotelemetry in rats treated with adenine (37%) than in vehicle-treated rats (16%), possibly explaining differences between our observations with Clark electrodes versus radiotelemetry. Renal expression of HIF-1α was less after 7 days of...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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