BioStruct-Africa: empowering Africa-based scientists through structural biology knowledge transfer and mentoring – recent advances and future perspectives

Being able to visualize biology at the molecular level is essential for our understanding of the world. A structural biology approach reveals the molecular basis of disease processes and can guide the design of new drugs as well as aid in the optimization of existing medicines. However, due to the lack of a synchrotron light source, adequate infrastructure, skilled persons and incentives for scientists in addition to limited financial support, the majority of countries across the African continent do not conduct structural biology research. Nevertheless, with technological advances such as robotic protein crystallization and remote data collection capabilities offered by many synchrotron light sources, X-ray crystallography is now potentially accessible to Africa-based scientists. This leap in technology led to the establishment in 2017 of BioStruct-Africa, a non-profit organization (Swedish corporate ID: 802509-6689) whose core aim is capacity building for African students and researchers in the field of structural biology with a focus on prevalent diseases in the African continent. The team is mainly composed of, but not limited to, a group of structural biologists from the African diaspora. The members of BioStruct-Africa have taken up the mantle to serve as a catalyst in order to facilitate the information and technology transfer to those with the greatest desire and need within Africa. BioStruct-Africa achieves this by organizing workshops onsite at our partner universit...
Source: Journal of Synchrotron Radiation - Category: Physics Authors: Tags: BioStruct-Africa structural biology neglected tropical diseases capacity building synchrotron remote data collection African Light Source teaching and education Source Type: research

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In this study, we detected for just the second time a SINV infection in a diseased wild bird (common wood pigeon) from Central Europe. SINV was isolated by cell culture and the complete SINV genome sequence was determined. Phylogenetic analyses revealed a close affiliation to SINV genotype I with a high similarity to human isolate sequences from Finland, Sweden and Russia. The isolate was genetically distinct from the first avian isolate suggesting the circulation of at least two different SINV strains in Germany.In order to reveal the infection frequency in SINV positive mosquito regions 749 bird blood samples were assaye...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
(Natural News) The official “Church of Sweden” has proclaimed climate eco-fascist Greta Thunberg to be the “successor” to Jesus Christ, proving once again that climate fanatics are members of a religious cult that worships the planet as a “god.” Towards the end of last year, the Church of Limhamn tweeted a bizarre “Announcement!” about young...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conclusion: Yellow fever vaccine may be a possible trigger for VKH. PMID: 31603703 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Isotope found in seabed sediment points to clash of solar bodies near Mars, study suggestsAstronomers have discovered intriguing evidence that an asteroid break-up blanketed Earth with dust millions of years ago. The event dramatically cooled the planet and triggered an ice age that was followed by major increases in numbers of new animal species.The work, led by Birger Schmitz of Lund University in Sweden, was recently published inScience Advancesand provides new insight into the impact of interplanetary events on our planet ’s evolution. “We know about the 10km asteroid that crashed on Earth 67 million years ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Space Evolution Asteroids World news Dinosaurs Fossils Climate change Source Type: news
At rally in Denver, Swedish activist again scolds leaders for ignoring scienceYoung people must be prepared to strike for a long time for action on climate change and not back down, the Swedish climate activist Greta Thunberg has told a rally in Denver.Thunberg said she and fellow youth activists would not beg those in power to act because she expected leaders to keep ignoring them.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Climate change Environment Climate science denial Source Type: news
ConclusionFew studies were found, which limits the possibility of drawing strong conclusions about cost effectiveness. There is some evidence based on decision-analytic modelling that anti-bullying interventions represent value for money. Generally, there is a lack of studies that take into account long-term costs and effects.Systematic Review Registration NumberCRD42019115882.
Source: Applied Health Economics and Health Policy - Category: Health Management Source Type: research
Sensors, Vol. 19, Pages 4414: Temperature Impact in LoRaWAN—A Case Study in Northern Sweden Sensors doi: 10.3390/s19204414 Authors: Níbia Souza Bezerra Christer Åhlund Saguna Saguna Vicente A. de Sousa Jr. LoRaWAN has become popular as an IoT enabler. The low cost, ease of installation and the capacity of fine-tuning the parameters make this network a suitable candidate for the deployment of smart cities. In northern Sweden, in the smart region of Skellefteå, we have deployed a LoRaWAN to enable IoT applications to assist the lives of citizens. As Skellefteå has a subarc...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
ConclusionA large proportion of individuals having undergone GBP surgery reported problems with their oral health and impacts on their OHRQoL, indicating a need for medical and dental staff —surgeons and general practitioners as well as other health professionals—to offer oral health promotion and prevention measures.
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionsThe MSKCC nomogram, CAPRA score, and CPG risk grouping system performed better in discriminating prostate cancer death than the D’Amico and D’Amico-derived systems (NICE, GUROC, EAU, AUA, and NCCN). Use of these tools may improve clinical decision making.Patient summaryThere are numerous pretreatment risk classification tools that can aid treatment decision for prostate cancer. We systematically compared the prognostic performance of the most commonly used tools in a large cohort of Swedish men with prostate cancer. The Memorial Sloan Kettering Cancer Center nomogram, Cancer of the Prostate Risk Asse...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Conditions:   Lymphatic Filariasis Elimination by Mass Drug Administration;   Monitoring and Evaluation of Mass Drug Administration for Lymphatic Filariasis;   Acceptability of Mass Drug Administration for Lymphatic Filariasis Intervention:   Other: Observational Sponsors:   University Hospitals Cleveland Medical Center;   Case Western Reserve University;   Washington University School of Medicine;   Papua New Guinea Institute for Medical Research;   Papua New Guinea ENB ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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