Metabolomics by UHPLC –MS: benefits provided by complementary use of Q-TOF and QQQ for pathway profiling

ConclusionOur screening strategy combined the benefits of the unbiased full-scan HRMS acquisition with the deeper insight into specific pathways by large-scale QQQ analysis.
Source: Metabolomics - Category: Biology Source Type: research

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions: The results show that GLP-1 infusion suppresses the postprandial secretion of gastrin in normal subjects and even more so in the diabetes patients. The results may therefore shed further light on the upper gastrointestinal side effects of GLP-1-derived drugs in diabetic patients. PMID: 31725337 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
AbstractAimsPlatelets are pivotal in arterial thrombosis, and platelet hyperresponsiveness may contribute to the increased incidence of cardiovascular events in diabetes mellitus. Consequently, we hypothesized that increased in vitro platelet aggregation responses exist in men with diabetes mellitus.MethodsThe Danish Cardiovascular Screening Trial (DANCAVAS) is a community-based cardiovascular screening trial including men aged 65 –74 years. Platelet aggregation was tested using 96-well light transmission aggregometry with thrombin receptor-activating peptide (TRAP), adenosine diphosphate, collagen type 1, arach...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
ConclusionsThe clinical decision regarding timing of delivery is complex and contingent on maternal ‐fetal wellbeing, including adequate glycemic control. This study suggests that delivery at 38, 39, or 40 weeks may optimize neonatal outcomes among women with diabetes.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Pocket-size ultrasound devices that cost 50 times less than the machines in hospitals (and connect to your phone). Virtual reality that speeds healing in rehab. Artificial intelligence that’s better than medical experts at spotting lung tumors. These are just some of the innovations now transforming medicine at a remarkable pace. No one can predict the future, but it can at least be glimpsed in the dozen inventions and concepts below. Like the people behind them, they stand at the vanguard of health care. Neither exhaustive nor exclusive, the list is, rather, representative of the recasting of public health and medic...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized HealthSummit19 technology Source Type: news
CONCLUSIONS: Subjects with T1D with sufficient exposure to recurrent hypoglycemia to create IAH did not have alteration of Tmax/CMRglc or neurochemical profile compared to participants with T1D-NAH or HC. PMID: 31637440 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
ConclusionsThis case report demonstrates an unusual etiology of back and leg pain in a young man and elucidates the palliative effects of radiation therapy for epithelioid hemangioma involving the lumbar spine.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Abstract The transient receptor potential canonical 6 (TRPC6) channel and podocin are co-localized in the glomerular slit diaphragm as an important complex to maintain podocyte function. Gain of TRPC6 function and loss of podocin function induce podocyte injury. We have previously shown that high glucose induces apoptosis of podocytes by activating TRPC6; however, whether the activated TRPC6 can alter podocin expression remains unknown. Western blot, confocal microscopy, and scanning ion conductance microscopy were used to examine both the expression levels of TRPC6, podocin, and nephrin and the morphological chan...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
Conditions:   Diabetes Mellitus, Type 1;   Bone Fracture;   Bone Health Interventions:   Diagnostic Test: Clinical tests;   Diagnostic Test: Biochemical tests;   Diagnostic Test: DXA scan;   Diagnostic Test: AGE Reader Sponsor:   CHU de Quebec-Universite Laval Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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