Removal of DNA-fragmented spermatozoa using flow cytometry and sorting does not improve the outcome of intracytoplasmic sperm injection

ConclusionsA trend towards consistently better results was achieved by removing spermatozoa with fragmented DNA. The fragmentation of the DNA in sperm is the end stage of apoptosis. Sorting of spermatozoa may be improved by selecting parameters of processes active more upstream of apoptosis, such as chromatin decondensation.Trial registrationNCT02166567. June 14, 2014.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research